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| Effect of Frozen Thawed Embryo Transfer Cycle and Transplantation Time on Pregnancy Outcome in Patients with Repeated Implant Failure |
| HU Jing |
| Department of Reproductive Medicine, the Second People's Hospital of Yunnan, Kunming 650021, Yunnan, China |
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Abstract 【Objective】To analyze the effect of frozen-thawed embryo transfer (FET) cycle time on pregnancy outcome in patients with repeated RIF failure (repeated implantation failure).【Methods】A total of 80 patients with RIF undergoing FET in the hospital were randomly divided into control group and observation group, 40 cases in each group. The combination of down-regulation and hormone replacement was used for FET; In the control group, the embryos were transplanted at 3 d after progesterone administration; The observation group was delayed 4~5 D and underwent embryo transfer, and the changes of sex hormone levels and pregnancy outcomes were compared between the two groups.【Results】①There was no significant difference between the two groups in the number of embryos transferred, the number of high-quality embryos transferred, and the thickness of endometrium on the day of transplantation (P＞0.05). ②Before transplantation, there was no statistically significant difference in sex hormone levels between the two groups (P＞0.05). On the day of transplantation, the levels of luteinizing hormone (LH),follicle stimulating hormone (FSH) and progesterone (P) in observation group were lower than those in the control group, while estradiol (E2) level was higher than that in the control group (P＜0.05). ③The clinical pregnancy rate of the observation group was higher than that of the control group (P＜0.05), and the embryo implantation rate was slightly higher than that in the control group. The rates of early abortion, ectopic pregnancy and multiple pregnancy were slightly lower than those in control group (P＞0.05). 【Conclusion】The delayed application of down regulation combined with hormone replacement for FET can improve the endometrial receptivity and the clinical pregnancy rate of patients with RIF.
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Received: 19 February 2017
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2017, Vol. 34 
