胰岛素与口服降糖药治疗初诊T2DM患者疗效的Meta分析

doi:10.3969/j.issn.1671-7171.2017.08.018

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Abstract 【Objective】To systematically review the efficacy and safety of insulin and oral anti-diabetic drugs in the treatment of newly diagnosed type 2 diabetes (T2DM) patients. 【Methods】We searched the database to collect published randomized controlled trials (RCTs) of insulin therapy and oral anti-diabetic drugs(OADs) in the treatment of newly diagnosed T2DM patients. Clinical characteristics and references' quality were evaluated by Cochrane bias risk assessment tools. The Meta-analysis was performed by using the RevMan 5.3 software. 【Results】Ten articles including a total of 807 cases were analyzed. The meta-analysis shows that:① in the patients of newly diagnosed diabetes, the reductions of FPG, 2hPG and HbA1c were significantly more than in insulin group than in OADs group;② the improvement of β-cell function (HOMA- β) and remission rate were significantly better in insulin group than in OADs group;③ there were no significant difference in hypoglycemic events or weight changes during treatment between the two groups. 【Conclusion】For newly diagnosed type 2 diabetes, initial use of insulin therapy can more effectively control blood glucose, and relieve HOMAβ compared to use of OADs. There were no significant difference in hypoglycemic events and body weight changes of the two treatments.

Key words： Diabetes Mellitus, Type 2/DT Insulin Hypoglycemic Agents/AD Administration, Oral Meta-Analysis

Received: 01 August 2016

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R587.1

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	LI Yue
	XU Li-mei
	XIONG Zai-dao

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LI Yue,XU Li-mei,XIONG Zai-dao. Meta-analysis of Efficacy and Safety of Insulin and Oral Anti-diabetic Drugs in the Initial Treatment of Newly Diagnosed Type 2 Diabetes[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1511-1514,1517.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.08.018 OR http://www.jcr.net.cn/EN/Y2017/V34/I8/1511

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