吲哚菁绿排泄试验评估耐药肺结核患者在抗结核治疗过程中肝脏损伤的价值

doi:10.3969/j.issn.1671-7171.2017.08.009

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Abstract 【Objective】To assess the value of indocyanine green excretion test in predicting liver injury in patients of multidrug-resistant tuberculosis(MDR-TB) during antituberculosis treatment.【Methods】Clinical data of 137 patients with drug-resistant pulmonary tuberculosis treated in our hospital from January 2015 to December 2016 were analyzed retrospectively. 1d before the start of antituberculosis treatment and the first month and the third month after the start of treatment, indocyanine green (ICG) excretion test was carried out respectively to assess the patient's liver function; The ICG plasma clearance rate (PDRICG) and the 15 min retention rate (R15ICG) of ICG were detected and compared with the conventional liver function index.【Results】One month of after anti TB treatment, the patient's PDRICG decreased significantly and R15ICG increased significantly (P=0.007, 0.001); 3 months after treatment, PDRICG and R15ICG recovered significantly and almost returned to pre treatment levels (P=0.002,0.001); The levels of PDRICG and R15ICG were significantly worse before treatment (P=0.01,0.016) in patients with liver injury; Before the start of treatment, and in the first month and three months after the start of treatment, the PDRICG and R15ICG were significantly positively correlated with the corresponding time points of TBil (r=0.816 and 0.1767,P＜0.001),and significantly negatively correlated with PA (r=-0.312 and -0.423,P＜ 0.001) and ALB (r=-0.231 and -0.177,P＜0.001); there was no significant correlation between ALT, AST, PT, and INR (P＞0.05).【Conclusion】PDR and R15 are valuable clinical trials to evaluate the liver injury in drug-resistant tuberculosis patients during anti-tuberculosis treatment and are worthy of popularization in clinical practice.

Key words： Indocyanine Green/ME Tuberculosis, Pulmonary/DT Drug Tolerance Liver/IN Antitubercular Agents

Received: 16 May 2017

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R521

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	GU Qiang-ye
	WANG Fei
	YANG Jian-xin

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GU Qiang-ye,WANG Fei,YANG Jian-xin. Value of Indocyanine Green Excretion Test in Predicting Liver Injury in Patients of Multidrug-resistant Tuberculosis during Antituberculosis Treatment[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(8): 1483-1486.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.08.009 OR http://www.jcr.net.cn/EN/Y2017/V34/I8/1483

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