2型糖尿病患者正常范围内血清直接胆红素不同水平与血脂异常的相关性及其危险因素分析

doi:10.3969/j.issn.1671-7171.2017.07.024

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Abstract 【Objective】To analyze the correlation between normal (0~6.89 μmol/L) serum direct bilirubin (DBiL) levels and blood lipids in patients with type 2 diabetes mellitus (T2DM) and to predict the related risk factors of dyslipidemia. 【Methods】The clinical data of 380 cases with T2DM were collected, and the levels of DBil, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglyceride (TG) and total cholesterol (TC) were recorded. According to the DBil levels, the subjects were divided into group A (＜ 2.2 μmol/L,n=92), group B (2.2~2.9 μmol/L,n=88), group C (2.9~3.9 μmol/L,n=102), and group D (3.9~6.89 μmol/L,n=98). The correlation between TBil and serum lipid was analyzed. 【Results】The proportions of male patients, smoking and drinking, high TC hyperlipidemia, high TG hyperlipidemia, insulin treatment, and the levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), postprandial 2h blood glucose (2hPG), glycosylated hemoglobin (HbA1c), total bilirubin (TBil), DBil, TC, TG and LDL-C showed significant differences among the four groups (P＜0.05). The incidence of dyslipidemia and levels of TC, TG and LDL-C in group D were lower than those in group A. The DBil level was negatively correlated with the levels of TC, TG and LDL-C in patients with T2DM (P＜0.05). The risk of dyslipidemia was the lowest in group D among the four groups. 【Conclusion】There is a correlation between normal DBil and blood lipids in patients with T2DM, and high DBil can decrease the risk of dyslipidemia.

Key words： Diabetes Mellitus, Type 2 Bilirubin/BL Dyslipidemias Risk Factors

Received: 28 November 2016

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R587.1

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.07.024 OR http://www.jcr.net.cn/EN/Y2017/V34/I7/1322

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