|
|
|
| Effect of Subclinical Hypothyroidism with Gestational Hypertension on Maternal and Neonatal Outcomes |
| CHEN Xiao-ling |
| Department of Obstetrics and Gynecology, People's Hospital of Pengzhou, Sichuan, 611930, China |
|
|
|
|
Abstract 【Objective】To investigate the effect of subclinical hypothyroidism (SCH) and gestational hypertension on maternal and neonatal outcomes. 【Methods】 A total of 90 patients with gestational SCH treated in the hospital from May 2014 to March 2016 and 40 healthy volunteers (the healthy group) who received antenatal care in the same period were selected as subjects. According to the blood pressure measured after 25~28 weeks of pregnancy, the patients with gestational SCH were divided into the combined group (48 cases of SCH with gestational hypertension) and the control group (42 cases of SCH without hypertension). The thyroid function [thyroid stimulating hormone (TSH), free thyroxine (FT4), thyroid peroxidase antibody (TPO-Ab)], blood lipid levels [triglyceride (TG), serum total cholesterol (TC), low-density lipoprotein (LDLC)], maternal and neonatal outcomes, and the incidence of pregnancy complications were compared among the three groups. 【Results】 The levels of TSH and TPO-Ab in the combined group were significantly higher than those in both the control group and the healthy group, while FT4 was lower. The levels of TG, TC and LDLC were the highest in the combined group and followed by the control group, and those in the healthy group were the lowest. There were significant differences between any two groups (P＜0.05). The total incidence of adverse maternal and neonatal outcomes, and pregnancy complications in the combined group were the highest (47.92%, 31.25%), followed by the control group (16.67%, 11.90%), and the incidence was lowest in the healthy group (2.50%, 0.00%). There were significant differences between any two groups (P＜0.05). 【Conclusion】 SCH is closely related to pregnancy-induced hypertension, which may be related to abnormal lipid metabolism. The total incidence of adverse maternal and neonatal outcomes in patients with SCH complicated with pregnancy-induced hypertension is significantly higher than that in pregnant women with single disease or healthy pregnant women.
|
|
Received: 19 December 2016
|
|
|
|
|
|
[1] 李春仙,陈敏,李美红,等.妊娠妇女亚临床甲状腺功能减退症对妊娠结局的影响[J].中华内分泌代谢杂志,2015,31(11):937-940.
[2] 孔丽丽,周金华,黄沁,等.妊娠合并亚临床甲状腺功能减退症的早期治疗对妊娠结局的影响[J].实用妇产科杂志,2014,30(12):937-939.
[3] 雍莉,高慧,张秀东,等.妊娠高血压终止妊娠的时机和分娩方式的选择[J].西部医学,2014,26(5):631-632,635.
[4] 杨娉,肖俏.亚临床甲状腺功能减退与妊娠期高血压疾病关系的探讨[J].中国妇产科临床杂志,2015,16(4):357-359.
[5] Jian WX,Jin J,Qin L,et al. Relationship between thyroid-stimulating hormone and blood pressure in the middle-aged and elderly population[J].Singapore Med J,2013,54(7):401-405.
[6] 郑冬梅,李升华,王娟,等.妊娠期高血压疾病对新生儿出生结局及脐动脉血流的影响[J].解放军医学杂志,2013,38(9):757-759.
[7] 秦小霞.妊娠合并亚临床甲状腺功能减退症的早期治疗对妊娠结局的影响分析[J].医学理论与实践,2016,29(5):652-653.
[8] 郭朋鸽,解冰洁,彭婷婷,等.妊娠合并亚临床甲状腺功能减退症及其治疗对妊娠结局的影响[J].中国妇幼保健,2016,31(12):2428-2431.
[9] 王益群.妊娠期高血压疾病相关影响因素及对妊娠结局影响的研究[J].中华全科医学,2015,13(4):602-604.
[10] Mannisto T.Karumanchi SA.Pouta A,et al.Preeclampsia gestational hypertension and subsequent hypothyroidism[J].Pregnancy Hypertens,2013,3(1): 21-27.
[11] Riabtseva OIu,Orlova IaA,Blankova ZN,et al.The vascular wall in postmenopausal women with hypothyroidism and hypertension[J].Ter Arkh,2013, 85(10):64-69.
[12] Rezzonico J,Niepomniszcze H,Rezzonico M,et al.The association of insulin resistance with subclinical thyrotoxicosis[J].Thyroid,2011,21(9):945-949.
[13] 李超华,方丽丽.妊娠高血压疾病的发病因素与母婴不良结局的关系[J].安徽医学,2016,37(1):31-34.
[14] 王燕.138例孕妇早产高危因素及母婴结局[J].医学临床研究,2014,37(2):352-353.
[15] 符倩莉.妊娠高血压加强优质护理对母婴结局影响[J].心血管病防治知识, 2016,26(7):27-28.
[16] 赵叶芳,王炳杰,焦亚楼,等.亚临床甲状腺功能减退合并妊娠期糖尿病对妊娠结局的影响[J].现代预防医学,2016,43(3):443-445. |
|
|
|
2017, Vol. 34 
