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| Effect of Propofol Combined with Remifentanil Intravenous Anesthesia on Preoperative Signs and Related Factors in Patients with Liver Cancer during Radiofrequency Ablation |
| XIAN Lian-yan, ZHAO Jing |
| The Maternal and Chind Health Hospital of MianYang City, Shichuan Province 621000 |
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Abstract 【Objective】To investigate the effect of propofol combined with remifentanil intravenous anesthesia on signs, serum high-mobility group protein B1 (HMGB1) and cytokines in patients with liver cancer during radiofrequency ablation (RFA). 【Methods】A total of 76 patients with liver cancer treated with RFA in our hospital were divided into the remifentanil combined with propofol group (A group) and fentanyl combined with propofol group (B group) by random, with 38 cases in each group. The recovery time, VAS pain score and incidence rate of intraoperative complications were compared between the two groups. The changes of HR, MAP and SpO2 before operation (T 0), at 5 min after the beginning of RFA (T 1 ), immediately at the end of RFA (T 2 ) and at recovery (T 3 ) were recorded. The tumor necrosis factor α (TNF- α), interleukin -6 (IL-6) and HMGB1were compared before and after operation. 【Results】The recovery time of A group was shorter than B group, and the VAS pain score was lower than B group (P＜0.05). There was no significant difference in SpO2 between the two groups at different time points (P＞0.05). Compared to T 0 , MAP of the two groups was lower at T 1 , and the MAP of A group was higher than B group. From T 1～2 , HR of the two groups decreased, and HR of A group was lower than B group (P＜0.05). There was no significant difference at other time points (P＞0.05). TNF-α, IL-6 and HMGB1 were lower in A group than B group (P ＜ 0.05). There was no significant difference in the incidence of complications between the two groups (P＞0.05). 【Conclusion】Propofol combined with remifentanil intravenous anesthesia is effective in the anesthesia of RFA for liver cancer. It can better regulate inflammatory factors, although the pseudoalveolus respiratory monitoring is needed during operation.
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Received: 30 January 2017
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2017, Vol. 34 
