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| Correlation Analysis of Activity of FⅦ and Coagulation Function in Patients with Traumatic Brain Injury |
| SUN Xiu-hai, DAI Xue-liang, LIU Hong-yi |
| Department of Neurosurgery, Zoucheng People's Hospital, Shandong 273500, China |
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Abstract 【Objective】To investigate the plasma coagulation factor Ⅶ activity and its correlation with blood coagulation function in patients with acute craniocerebral trauma.【Methods】Ninety-two patients with acute craniocerebral trauma treated in our hospital from March 2014 to March 2016 were selected as the observation group, At the same time, 92 healthy volunteers in our hospital for the same period were selected as the control group, FⅦ activity value, the activated partial thromboplastin time (AFFF), platelet (PLT), two D- dimer, fibrinogen (FIB), hemoglobin (Hb), blood lactate (Lac) and other related blood coagulation index,were detected in the two groups. The international normalized ratio (INR) was calculated and intracranial pressure (ICP) was measured. The correlation between the observation group and the control group plasma FⅦ activity and its coagulation indexes were compared.【Results】FⅦ activity value of plasma of the observation group was (91.45±32.10)%, that of the control group was (97.20±16.03)%, two groups had no statistically significant difference (t=-1.537,P>0.05).INR, APTT and Lac were significantly higher than that of plasma F activity in patients with high plasma activity FⅦ. The plasma FIB level was significantly lower than that of plasma FⅦ high activity, the differences were statistically significant (P<0.05). abnormal coagulation function in patients of the observation group counted a total of 35 cases, the plasma activity of FⅦ was (86.70±28.84)%, 57 patients was accompanied with coagulation dysfunction in the observation group, The plasma activity of FⅦ was (97.83±30.16)%, there were significant differences between the two groups (t=-2.176,P<0.05).【Conclusion】Plasma activity FⅦ in patients with acute craniocerebral trauma is related to coagulation function, Plasma activities FⅦ in patients with abnormal coagulation function decreased, which is worthy of further clinical research.
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Received: 12 January 2017
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(本文编辑:张兴珍) [收稿日期] 2017-01-12
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2017, Vol. 34 
