血清Vaspin、CTRP9在多囊卵巢综合征患者中的表达及其意义

doi:10.3969/j.issn.1671-7171.2017.06.012

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Abstract 【Objective】To investigate the expression and significance of serum Vaspin and CTRP9 levels in patients with polycystic ovary syndrome. 【Methods】 Fifty-nine cases diagnosed PCOS patients from March 2015 to August 2016 in our hospital (observation group) were selected, according to the body mass index [(BMI) WHO obese than 25kg/m²] they wee divided into non obese group A (28 cases), obesity group B (31 cases ); In addition, 60 healthy women (control group) who underwent physical examination in our hospital were divided into non obese 31 cases (control group A) and obesity 29 cases (control group B) according to BMI. Detection and comparison of four groups of patients with serum Vaspin, CTRP9 levels were compared between the four groups in general and biochemical indicators such as three triglycerides (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting insulin resistance index (FINS), total testosterone and insulin (HOMA-IR), and the level of steady period of 120 to 180 min glucose metabolic rate (M120-180).【Results】 The serum Vaspin level of the observation group was significantly higher than that of the control group, and the serum CTRP9 level was significantly lower than that of the control group, the difference was statistically significant (P<0.05); Pearson correlation analysis showed that the level of Vaspin was negatively correlated with HDL-C and M120-180 (P<0.05), and positively correlated with BMI, TC, LDL-C, waist circumference, FINS, TG, total testosterone, and HOMA-IR levels (P<0.05); The level of CTRP9 was positively correlated with HDL-C and M120-180 (P<0.05), and negatively correlated with BMI, TC, LDL-C, waist circumference, FINS, TG, total testosterone and HOMA-IR levels (P<0.05); Serum levels of Vaspin and CTRP9 were not significantly correlated with age (P>0.05). 【Conclusion】 Compared with the healthy population, PCOS patients have higher serum Vaspin levels and lower CTRP9 levels; The indexes of BMI, TC, HDL-C, waist circumference, FINS, TG, total testosterone, HOMA-IR, LDL-C and M120-180 were closely related to serum levels of Vaspin and CTRP9.

Key words： Polycystic Ovary Syndrome Serine Proteinase Inhibitors/BL Insulin Resistance Body Mass Index

Received: 01 April 2017

PACS:

R711.75

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	WANG Yu-hong
	ZHANG Zhon-qiang
	LU Jing

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WANG Yu-hong,ZHANG Zhon-qiang,LU Jing. Expression and Significance of Serum Vaspin and CTRP9 Levels in Patients with Polycystic Ovary Syndrome[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1081-1084,1086.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.06.012 OR http://www.jcr.net.cn/EN/Y2017/V34/I6/1081

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(本文编辑:邓丽萍) [收稿日期] 2017-04-01