骨肽注射液对维甲酸所致大鼠骨质疏松的治疗作用及其机制

doi:10.3969/j.issn.1671-7171.2017.06.008

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Abstract 【Objective】 To explore the mechanism and effect of Ossotide injection on osteoporosis induced by retinoic acid in rats. 【Methods】 Fifty SD rats were randomly divided into normal control group, model control group, Ossotide injection low, medium and high groups. In addition to normal control group, and the other four groups were intraperitoneally injected with 70 mg/kg retinoic acid for 14 days. Ossotide injection low, medium and high groups were intragastrically administrated with 100, 200, 400 μg/(kg·d) Ossotide injection, the normal control group and the model control group were given equal amount of normal saline for 4 weeks. The rat bone mass, bone mineral density was observed and recorded. The level of calcium, phosphorus and alkaline phosphatase (ALP) in serum was detected by automatic biochemical analyzer method. The level of serum tartrate resistant acid phosphatase (TRACP) activity and osteocalcin content was detected by kit. 【Results】Compared with normal group, the level of calcium and phosphorus in serum, bone mass, bone mineral density was decreased (P<0.01), the activity of ALP and TRACP was increased (P<0.01), the level of osteocalcin was increased in model group (P<0.01). Compared with model control group, the level of calcium and phosphorus, bone mass, bone mineral density in serum was increased (P<0.01), the activity of ALP and TRACP was decreased (P<0.01), the level of osteocalcin was decreased in Ossotide injection low, medium and high group (P<0.01). 【Conclusion】Ossotide injection could treat retinoic acid induced osteoporosis in rats.

Key words： Peptides/TU INJECTIO Tretinoin/AE Osteoporosis/ET Osteoporosis/DT BONES/ME

Received: 09 January 2017

PACS:

R681.4

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.06.008 OR http://www.jcr.net.cn/EN/Y2017/V34/I6/1069

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(本文编辑:邓丽萍) [收稿日期] 2017-01-09