孕早期脂代谢异常对妊娠期糖尿病发病率的影响

doi:10.3969/j.issn.1671-7171.2017.06.004

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Abstract 【Objective】To explore the effects of abnormal lipid metabolism in early pregnancy on the incidence rate of gestational diabetes mellitus (GDM).【Methods】A total of 120 pregnant women with abnormal lipid metabolism in the early pregnancy were selected as the observation group, and other 120 pregnant women with normal lipid metabolism in the early pregnancy were selected as the control group. The levels of serum lipid metabolism indexes cholesterol(TC), triglyceride (TG), low density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol (HDL-C), adipocytokine leptin, free fatty acid, blood glucose and insulin resistance indexes fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), fasting membrane insulin (FINS), insulin resistance index (HOMA-IR) were measured in the two groups. The correlation of TG, leptin and blood glucose and insulin resistance indexes was analyzed, and the incidence rate of GDM, pregnancy outcome, fetal and related complications were analyzed in two groups.【Results】Compared with the control group, the levels of TG, TC and LDL-C in the observation group were significantly higher while the level of HDL-C was significantly lower (P<0.05), and leptin and free fatty acid were significantly higher (P<0.01). At the same time, the levels of blood glucose indexes FBG, HbAlc and HOMA-IR were significantly higher in the observation group, and the insulin resistance index FINS was significantly lower (P<0.01). Univariate correlation analysis showed that the levels of TG and leptin were positively correlated with FBG, HbAlc and HOMA IR, but negatively correlated with FINS (P<0.05). The incidence rate of GDM was 35% in the observation group, which was significantly higher than that in the control group with16.67%% (P<0.05). Compared with the control group, the spontaneous labor rate of the observation group was significantly lower, and the cesarean section rate was significantly higher (P<0.05). And the incidence rates of fetal distress and macrosomia in the observation group were significantly higher than those of the control group (P<0.05).【Conclusion】Early pregnancy lipid metabolism abnormalities which contains the abnormal lipids, adipocytokine levelscan significantly increase the incidence rate of GDM, and affect the pregnancy outcome of pregnant women and fetal birth.

Key words： Pregnancy Trimester, First Lipid Metabolism Disorders Diabetes, Gestational Incidence Pregnancy Outcome

Received: 12 March 2017

PACS:

R714.256

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.06.004 OR http://www.jcr.net.cn/EN/Y2017/V34/I6/1054

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(本文编辑:邓丽萍) [收稿日期] 2017-03-12