入院24小时内急性百草枯中毒患者预后的影响因素

doi:10.3969/j.issn.1671-7171.2017.06.003

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (0 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract 【Objective】To investigate the risk factors of acute paraquat poisoning in patients who were hospitalized within 24 hours. 【Methods】 A total of 123 patients with acute paraquat poisoning were divided into survival group (n=46) and death group (n=77) from Jan. 2009 to Aug. All patients were recorded and analyzed for general information (gender, age, oral dose of paraquat, time to gastric lavage and perfusion, number of perfusions), concentration of paraquat at admission, worst APACHE Ⅱ score within 24 hours, blood gas analysis, blood Routine, urine, liver and kidney function, myocardial enzymes, electrolytes and other biochemical indicators. The differences of the indexes between the two groups were compared and the prognostic risk factors were analyzed. 【Results】 There was no significant difference in the age and the difference between the survival group and the death group (P>0.05). The survival dose and the concentration of paraquat in the surviving group were lower than those in the death group (P<0.05), but there was no significant difference between perfusion time and perfusion time. The levels of AST(Aspartate aminotransferase), Tbil(Serum total bilirubin), BUN(Urea nitrogen) and CK(Creatine kinase) in the survivors group and the death group were significantly higher than those in the survivors group (P<0.05); the levels of leukocyte, ALT(Alanine aminotransferase) and Cr(Creatinine) in the dead group were significantly higher than those in the survival group (P>0.05). The levels of pH, HCO₃^-, PaO₂ and PaCO₂ in the death group were lower than those in the survival group (P<0.05). The lactate level and APACHE Ⅱ score of the death group were higher than those of the survival group (P<0.05). Multivariate Logistic regression analysis showed that the concentration of blood paraquat, WBC, lactic acid, toxin, pH and K⁺ were the risk factors of acute paraquat poisoning. 【Conclusion】 The levels of blood paraquat, WBC, lactic acid, toxication, pH and K⁺ were the risk factors of early death in patients with acute paraquat poisoning, and with the high prognostic value.

Key words： Paraquat/PO Acute Disease Poisoning/TH Prognosis Risk Factors

Received: 25 November 2016

PACS:

R595

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors

Cite this article:

URL:

http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.06.003 OR http://www.jcr.net.cn/EN/Y2017/V34/I6/1051

[1] 陈芳, 刘智玲, 韩小彤. 百草枯中毒的急救及其预后影响因素分析[J].医学临床研究, 2014,31(8):1551-1554.
[2] 中国医师协会急诊医师分会.急性百草枯中毒诊治专家共识(2013)[J].中国急救医学, 2013,33(6):484-492.
[3] 周登川, 凌祥,周承藩, 等. 急性百草枯中毒患者病情及预后评价指标的研究进展[J].中华劳动卫生职业病杂志, 2016,34(5):393-397.
[4] Kim HJ, Kim HK, Lee H,et al.Toxicokinetics of paraquat in Korean patients with acute poisoning[J].Korean J Physiol Pharmacol,2016,20(1):35-39.
[5] 何鸣, 郑坚. 急性百草枯中毒患者早期脏器功能改变及预后相关性分析[J].浙江临床医学,2015,17(6):899-902.
[6] 杜宇, 牟奕. 三种方法对急性百草枯中毒严重程度好预后评估价值的比较[J].中南大学(医学版), 2013,28(7):737-740.
[7] 何佳起, 李敬, 李颖,等. 和肽素、APACHEⅡ评分在评估急性百草枯中毒患者预后的价值[J]. 医学临床研究, 2014, 31(8):1492-1494.
[8] Wang S, Wang Z, Chen D,et al.Effect of acute paraquat poisoning on CYP450 isoforms activity in rats by cocktail method[J].Int J Clin Exp Med,2015,8(10):19100-19106.
[9] Sun B, Chen Y.A simple and rapid method for detection of paraquat in human plasma by high-performance liquid chromatography[J].Int J Clin Exp Med,2015,8(10):17067-17071.
[10] 才权, 刘志. 急性百草枯中毒早期死亡相关因素分析[J].中华危重病急救医学, 2014,26(6):379-382.
[11] Wen C, Wang Z, Zhang M,et al.Metabolic changes in rat urine after acute paraquat poisoning and discriminated by support vector machine[J].Biomed Chromatogr,2016,30(1):75-80.
[12] 陈芳, 刘智玲, 韩小彤. 百草枯中毒的急救其及预后影响因素分析[J]. 医学临床研究, 2014, 31(8):1551-1553.
(本文编辑:邓丽萍) [收稿日期] 2016-11-25