厚朴酚抑制体外乳腺癌细胞株生物活性的实验研究

doi:10.3969/j.issn.1671-7171.2017.06.002

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Abstract 【Objective】To investigate the effects of Magnolia (Magnolol, Mag) that inhibited the biological activity of different breast cancer cell lines in vitro. 【Methods】 Human breast cancer high metastatic cell lines MCF-7 and MDA-MB-231 were used in the study. Different concentrations of Mag solution were added to the culture medium to observe the rate of apoptosis, invasion, migration and adhesion capacity. Then, the effects of Mag on biological activity of breast cancer cell line were evaluated. 【Results】Data showed that Mag inhibited the rate of apoptosis, invasion, metastasis and adhesion ability in two breast cancer cell lines (P<0.05), and that with the increase of Mag concentration, the inhibitory activity on the biological activity was increased (P<0.05). 【Conclusion】Mag can inhibit the biological activities of breast cancer cell lines by inhibiting the apoptotic rate, the ability of invasion, and the adhesion and migration of breast cancer cell lines.It has an important value in the treatment and prevention of breast cancer recurrence or metastasis in clinic.

Key words： MAGNOLOL/PD Breast Neoplasms/DT Tumor Cells, Cultured Neoplasm Metastasis Apoptosis

Received: 13 October 2016

PACS:

R737.9

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.06.002 OR http://www.jcr.net.cn/EN/Y2017/V34/I6/1047

[1] Li M, Zhang F, Wang X,et al. Magnolol inhibits growth of gallbladder cancer cells through the p53 pathway[J].Cancer Sci,2015,106(10):1341-1350.
[2] 王冬娥,陆羡.和厚朴酚的药理作用及其抗肿瘤的机制研究进展[J].医学综述,2009,15(11):1725-1727.
[3] Avtanski DB, Nagalingam A, Bonner MY, et al. Honokiol inhibits epithelial-mesenchymal transition in breast cancer cells by targeting signal transducer and activator of transcription 3/Zeb1/E-cadherin axis[J].Mol Oncol,2014,8(3):565-580.
[4] Zhang X, Huang H, Chang H, et al. Magnolol reduces bleomycin-induced rodent lung fibrosis[J].Int J Clin Exp Med,2015,8(9):15450-15457.
[5] 马亮,杨洋,申琳棱等.和厚朴酚对鼻咽癌细胞生长及其放射敏感性的影响[J].中华放射医学与防护杂志,2012,32(5):469-474.
[6] Ho JH-C, Hong C-Y. Cardiovascular protection of magnolol: cell-type specificity and dose-related effects[J].J Biomed Sci,2012,19(1):70.
[7] 崔婧.和厚朴酚联合TRAIL对人乳腺癌细胞株MCF-7效应的实验研究[J].医学信息(中旬刊),2011,24(7):3321-3322.
[8] Chen C, Tan R, Qu W, et al. Magnolol, a major bioactive constituent of the bark of Magnolia officinalis, exerts antiepileptic effects via the GABA/benzodiazepine receptor complex in mice[J].Br J Pharmacol,2011,164(5):1534-1546.
[9] 夏明钰,王敏伟,田代真一,等.厚朴酚通过改变Bax/Bcl-XL表达和激活caspase诱导人宫颈癌HeLa细胞凋亡[J].中国药理学通报,2005,21(3):318-322.
[10] Rasul A, Yu B, Khan M, et al. Magnolol, a natural compound, induces apoptosis of SGC-7901 human gastric adenocarcinoma cells via the mitochondrial and PI3K/Akt signaling pathways[J].Int J Oncol,2012,40(4):1153-1161.
[11] Yang L, Zhu L, Ge G, et al. Species-Associated Differences in the Inhibition of Propofol Glucuronidation by Magnolol[J].J Am Assoc Lab Anim Sci,2014,53(4):408-411.
[12] 张勇,唐方.厚朴酚药理作用的最新研究进展[J].中国中药杂志,2012,37(23):3526-3530.
(本文编辑:詹道友) [收稿日期] 2016-10-13