乌拉地尔、尼卡地平治疗老年高血压急症的临床疗效及安全性比较

doi:10.3969/j.issn.1671-7171.2017.06.024

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Abstract 【Objective】To compare the clinical efficacy and safety of urapidil and nicardipine in the treatment of elderly patients with essential hypertension. 【Methods】Sixty cases of elderly hypertensive patients admitted from January, 2015 to October, 2016 were selected as the study data . According to the principle of randomization, they were divided into urapidil group and nicardipine group, 30 cases in each group. Urapidil group was given intravenous injection of 12.5 mg, then given 50~200 g/min g/min urapidil continuous intravenous infusion; nicardipine group was given intravenous injection of nicardipine 1 mg, then 10~40 Mu A, continuous intravenous drip.In combination with the changes of blood pressure in patients, the dose of drugs was optimized and adjusted. The heart rate (HR), blood pressure changes and adverse reactions were observed before and after medication in two groups.【Results】The total effective rate of urapidil group was 90% (27/30), and the total effective rate was 93.33% (28/30) in the nicardipine group, but there was no significant difference between the two groups (P>0.05). 10 min, 20 min, 30 min, 60 min and 120 min SBP of two groups of patients were significantly lower than those before treatment; 60 min, 120 min DBP and HR of two groups were significantly lower than that before treatment, the differences were statistically significant (P<0.05); The HR of urapidil group was significantly lower than that of nicardipine group at 10 min, 20 min, 30 min, 60 min and 120 min, with statistical difference (P<0.05). Two groups of patients had different degrees of adverse reactions such as dry mouth, constipation, flushing during treatment, occurrence of adverse reaction rate of 6.7% (2/30) of the urapidil group was significantly lower than that of the nicardipine group (6/30 20%), with statistically significant differences between the groups (χ²=18.063,P<0.05).【Conclusion】Urapidil or nicardipine is effective in the treatment of elderly hypertensive emergencies, but the incidence of adverse events of urapidil is lower, and it has better drug safety.

Key words： Piperazines/TU Nicardipine/TU Hypertension/DT Emergencies Piperazines/AE

Received: 07 February 2017

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R544.1

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Cite this article:

LI Mu. Comparison of Efficacy and Safety of Urapidil and Nicardipine in Elderly Patients with Acute Hypertension[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(6): 1119-0.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.06.024 OR http://www.jcr.net.cn/EN/Y2017/V34/I6/1119

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(本文编辑:张兴珍) [收稿日期] 2017-02-07