血液透析联合血液灌流对糖尿病肾病患者微炎症状态的作用

doi:10.3969/j.issn.1671-7171.2017.03.025

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Abstract 【Objective】The aim of this study was to assess the effect of hemodialysis combined with hemoperfusion for the treatment of microinflammation in diabetic nephropathy patients. 【Methods】A total of 125 patients with diabetic nephropathy (DN) were divided into two group randomly. The observation group (n=66) received hemodialysis combined with hemoperfusion, and the control group (n=59) received hemodialysis therapy only. The status of curative effect and microinflammation which reflected as serum amyloid A(SAA),interleukin-6 (IL-6),IL-1β,tumor necrosis factor (TNF-α) and transforming growth factor (TGF-β1) were compared. 【Results】The effective rate of observation group was 60.61%, which was significantly higher than that in control group (45.760%) (P<0.05). After treatment,the levels of SAA, IL-6, IL-1β, TNF-α and TGF-β1 were significantly lower in the observation group than those in the control group. The differences were statistically significant (P<0.01). 【Conclusion】Hemodialysis combined with hemoperfusion can effectively decreased microinflammation status in diabetic nephropathy.

Key words： Renal Dialysis Hemoperfusion Diabetic Nephropathies Inflammation

Received: 06 December 2016

PACS:

R587.24

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Cite this article:

GOU Yan. A Controlled Study of Hemodialysis Combined with Hemoperfusion for the Treatment of Microinflammation in Diabetic Nephropathy[J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 493-495.

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.03.025 OR http://www.jcr.net.cn/EN/Y2017/V34/I3/493

[1]	. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 540-541.