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| Correlation between Cytokine Levels in Amniotic Fluid of Second Trimester with Spontaneous Preterm Delivery in Middle-aged Pregnant Women |
| LIU Jing |
| Jinniu Maternity and Child Health Hospital of Chengdu,ObstertricsDepartment,Chengdu Sichuan 610000 |
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Abstract 【Objective】To study the correlation between cytokine levels in amniotic fluid during the second trimester and spontaneous preterm delivery in middle-aged women. 【Methods】Forty-three pregnant women with spontaneous preterm delivery who were admitted to our hospital from March 2014 to November 2015 were selected as the premature group. Forty normal pregnant women were selected as the control group. The levels of cytokines (IL-16, IL-8, IL-6, CRP, and TNF-α ) were measured from amniotic fluid of the two groups, and the correlation of cytokines' level with spontaneous preterm delivery was analyzed. 【Results】The levels of IL-16, IL-8, IL-6, CRP and TNF-α in premature group were (201.37±18.74)pg/mL、(786.14±146.28)pg/mL,(141.25±13.87)pg/mL,(176.22±12.34)ng/mL, and(114.27±15.64)pg/mL, respectively, significantly higher than those in the control group[(157.46±10.43)pg/mL,(413.91±84.67)pg/mL,(122.94±8.63)pg/mL,(132.18±8.64)ng/mL, and(76.48±7.69)pg/mL], respectively. The differences were statistically significant (P<0.05). Through the logistic analysis of influencing factors, the levels of IL-16, IL-8, IL-6, CRP and TNF-α were found to be significantly correlated with the occurrence of spontaneous preterm birth in middle-aged women (P<0.05). 【Conclusion】 The level of cytokines in amniotic fluid of middle pregnancy is closely related to the occurrence of spontaneous preterm delivery in middle-aged pregnant women, and it can be used as early clinical screening indicators.
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Received: 06 January 2017
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[1] 叶彩霞.早期围生保健对预防早产降低早产发生率的临床探讨[J].中国医学前沿杂志(电子版),2014,6(6):79-81.
[2] 李丽(综述),王少华(审校).宫内感染致早产儿多器官功能损伤机制研究进展[J].医学综述,2015,11(7):1232-1234.
[3] Lim R,Barker G,Lappas M. Human cathelicidin antimicrobial protein 18 (hCAP18/LL-37) is increased in foetal membranes and myometrium after spontaneouslabour and delivery[J].J Reprod Immunol,2015,107: 31-42.
[4] 冯轶,蔺莉.自发性早产高危因素的分析[J].首都医科大学学报,2012,33(1):45-49.
[5] 温娜,张巧玉,王振国,等.细胞因子信号转导抑制因子3在早产和足月产胎盘组织中的不同表达[J].医学综述,2015,21(15):2828-2830.
[6] 虞娇,周琼洁,李笑天,等.早产预测的临床应用价值评价[J].中国计划生育和妇产科,2015,7(5):7-10.
[7] Ferguson KK , McElrath t , Chen YH , Longitudinal profiling of inflammatory cytokines and C-reactive protein during uncomplicated and preterm pregnancy[J].Am J Reprod Immunol,2014 ,72 (3): 326-336.
[8] 杨沐怿,刘乐南,李洁,等.中孕期羊水中细胞因子水平及解脲脲原体感染与自发性早产的关系[J].中华围产医学杂志,2016,19(4):263-268.
[9] 靳钰.IL-6、TNF-α、MMP-8与胎膜早破早产及宫内感染的关系[J].中国优生优育,2013,19(3):169-172.
[10] 包影,欧荣英,周美茜,等.未足月特发性羊水过少的临床处理及妊娠结局[J].中华全科医学,2015,13(1):72-74,93.
[11] 曲晓力,王子莲.早产的影响因素及预测方法[J].医学综述,2016,22(21):4249-4253.
[12] 安然,刘威,李雪,等.宫颈分泌物MMP-9、IL-6联合检测在预测早产中的诊断价值的研究[J].中国实验诊断学,2013,17(11):2044-2045.
[13] Shahshahan Z. The use of maternal C-reactive protein in the predicting of preterm labor and tocolytic therapy in preterm labor women[J].Adv Biomed Res,2014 ,3 :154.
[14] 吴琦.妊娠32～33+6周未足月胎膜早破新生儿结局的影响因素[J].中国妇幼保健,2016,31(20):4196-4199.
[15] 钟世林,邓玉清.2005-2014年我院早产相关高危因素变化的临床分析[J].齐齐哈尔医学院学报,2016,37(2):235-237.
[16] 杨沐怿,刘乐南,李洁,等.中孕期羊水中细胞因子水平及解脲脲原体感染与自发性早产的关系[J].中华围产医学杂志,2016,19(4):263-268.
[17] 殷吟.妊娠中期检测羊水中IL-6和IL-16水平预测早产的临床应用[J].南京医科大学学报,2016,13(11):15-18.
[18] 张雅,白润芳,李艳川,等.妊娠期糖尿病患者羊水量异常羊水成分分析及其对妊娠结局的影响[J].海南医学,2016,27(20):3310-3312.
[19] Lim R.Apelin is decreased with human preterm and term labor and regulates prolabor mediators in human primary amnion cells[J].Reprod Sci,2013 ,20 (8): 957-967.
[20] 张志慧.94例自发性早产相关高危因素分析[J].中国临床医生杂志,2016,44(5):95-97.
[21] 张聪,邢媛.联合检测宫颈阴道分泌物中胎儿纤维连接蛋白及白介素-6对早产的预测价值[J].实用临床医药杂志,2014,18(19):84-87.
[22] 蔡彦卿.α-MSH、IL-6和NF-κB在晚期流产和早产中的表达及意义[J].现代妇产科进展,2015,21(6):448-450.
[23] 丁晓颖,倪鑫,古航,等.促炎细胞因子在自发性早产中的研究进展[J].中国优生与遗传杂志,2014,6(4):58-62. |
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(1): 157-159. |
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2017, Vol. 34 
