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| Effect of Retroperitoneal Laparoscopic Radical Nephrectomy on Hepatic, Renal Function and Myocardial Enzymes in Perioperative Patients |
| MAO Fei, GU Shuo, ZHONG Bin,et al |
| The Affiliated Huaian Hospital of Nanjing Medical University,223000, China |
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Abstract 【Objective】To investigate the effect of retroperitoneal laparoscopic radical nephrectomy on liver,renal function and myocardial enzymes in patients with in perioperative period. 【Methods】A total of 80 patients with renal carcinoma who received surgical treatment in our hospital were analyzed.Forty two cases undergoing retroperitoneal laparoscopic radical nephrectomy were enrolled in the observation group, and 38 cases undergoing open radical nephrectomy were enrolled in the control group. The changes of liver function (ALT,AST), renal function (BUN,Cr ), myocardial enzymes (CK,CK-MB,LDH) and inflammatory factors (CRP,TNF-α, IL-6 ) were compared between the two groups. The operation complications in the two groups were recorded. 【Results】The intraoperative blood loss, hospitalization time and incidence of complications in the observation group were significantly less and lower than those in the control group (P<0.05). There were no significant level changes of ALT, AST, BUN, Cr, CK, CK-MB and LDH in observation group between pre and 24h post operation (P>0.05). While levels of ALT, AST and LDH at 24h post-operation in the control group were increased significantly (P<0.05). At 24h post-operation, the differences in ALT, AST and LDH between the two groups were significant (P<0.05). The levels of TNF-α, IL-6 and CRP at 24h post-operation in the two groups were significantly higher than those before operation (P<0.05), however, the above indexes in observation group were significantly lower than those in the control group (P<0.05). 【Conclusion】Retroperitoneal laparoscopic radical nephrectomy has the advantages of minimal trauma, faster postoperative recovery and few complications. It has little effect on hepatic and renal function as well as myocardial enzymes. Meanwhile, it has less influence on inflammatory factors, if compared to open operation.
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Received: 05 December 2016
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2017, Vol. 34 
