|
|
|
| Effect of Ginsenoside Rg3 Combined with Neoadjuvant Chemoradiotherapy on the Expression of VEGF and MTA1 Protein in Gastric Cancer Tissues and Prognosis |
| LI Xiang-wei, ZHANG Zheng-yuan, ZHOU Guang-rong |
| The First Affiliated Huaian Hospital of NanJing Medical University,Jiangsu Huai'an 223001 |
|
|
|
Abstract 【Objective】To study the effect of ginsenoside Rg3 combined with neoadjuvant chemoradiotherapy on the expression of VEGF and MTA1 protein in gastric cancer tissues, immune function and prognosis. 【Methods】A total of 84 patients with gastric cancer were randomized into the control group and the treatment group according to different methods of treatment. The control group was given neoadjuvant concurrent radiotherapy and chemotherapy before operation, while the experimental group was treated with ginsenoside Rg3 in addition to concurrent radiotherapy and chemotherapy. The changes of expression of VEGF and MTA1 protein, immune function and prognosis were compared between the two groups before and after treatment. 【Results】The RO resection rate and the total effective rate of the treatment group were higher than those of the control group (P<0.05). Compared to pretreatment, the positive rates of VEGF and MTA1 post-treatment in both groups were significantly reduced (P<0.05), and the decrease in the experimental group was significantly greater than that in the control group (P<0.05). After treatment, the percentage of CD3+ and CD4+, CD4+/CD8+ value and conversion rate of T cells in the experimental group increased significantly compared to the control group (P<0.05), while the percentage of CD8+ decreased significantly (P < 0.05). There was no significant difference in the incidence of bone marrow suppression between the two groups (P>0.05). The recurrence rate in the experimental group was low than the control group (P<0.05). The 1-year, 3-year and 5-year survival rates of the experimental group were higher than those of the control group (P<0.05). 【Conclusion】Ginsenoside Rg3 combined with neoadjuvant chemoradiotherapy in patients with gastric cancer shows higher RO resection rate. It can significantly lower the expression of VEGF and MTA1, improve body immunity, reduce recurrence rate, and increase the survival rate of patients. The effect is significant in clinical application.
|
|
Received: 08 September 2016
|
|
|
|
|
|
[1] 孙大鹏,鲁明明,王硕,等.人参皂苷Rg3通过Ca2+/CaM信号系统抑制胃癌BGC-823细胞增殖及其可能的机制[J].中国肿瘤生物治疗杂志,2015;22(2):225-229.
[2] 娄夏芳,赖春荣,黄纪缓,等.评估新评分体系在胃癌切除患者术后的有效性[J]. 医学临床研究,2016;33(2): 251-254.
[3] 汪劭婷,朱朝晖,李小毅.胃癌新辅助化疗疗效临床评价方法及进展[J].中国普外基础与临床杂志,2010;17(2):200-204.
[4] Kim BJ, Nah SY, Jeon JH, et al. Transient receptor potential melastatin 7 channels are involved in ginsenoside Rg3 induced apoptosis in gastric cancer cells [J]. Basic Clin Pharmacol Toxicol, 2011;109(4) : 233.
[5] 王维,李强,韩青松,等. HIF-α、VEGF和DLL4在非小细胞肺癌中的表达及临床意义[J].解放军医药杂志,2016;28(5):44-53.
[6] 姚远,李艳,赵鸿梅.MTA1在胃癌细胞系和胃癌组织中的表达定位以及临床意义[J].东南大学学报(医学版),2012;31(2):158-161.
[7] 于学涛,王淑萍.人参皂苷Rg3联合化疗治疗对胃癌术后患者的临床观察[J]. 中华肿瘤防治杂志,2010;17(10):779-781.
[8] 何斌,钱立庭,江浩.人参皂苷Rg3对鼻咽癌放疗患者细胞免疫功能的影响[J].安徽医科大学学报,2015;50(9):1293-1296. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(3): 565-567. |
|
|
|
|
2017, Vol. 34 
