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| Study on the Relationship between DNA Damage Repair Gene Polymorphism and 308nm Excimer Laser Treatment Effect for Vitiligo |
| ZHAO Lian-ying, LIU Dong-qing, LIU Bao-guo,et al |
| Affiliated Hospital of HeBei University of Engineering,Handan 056002,China |
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Abstract 【Objective】 To explore the relationship between DNA damage repair gene polymorphism and 308nm excimer laser treatment for vitiligo. 【Methods】 A total of 66 patients diagnosed with vitiligo from July 2015 to July 2016 were selected as the research subjects. All patients received the 308nm excimer laser treatment. Peripheral blood (1 mL) was drawn on the fasting morning before treatment to extract genome DNA. Direct sequencing was used for genotype of two SNP sites (ERCC1 C118T and XPC Lys939Gln). The relationship between DNA damage repair gene polymorphism and laser treatment effect of vitiligo was analyzed. 【Results】 Twenty-six out of sixty-six (39.39%) patients received less than or equal to 4 months treatment. Patients with more than 50% of vitiligo area skin color restoring accounted for 34.85%. The first skin color restoring time for less than or equal one month accounted for 75.76%. ERCC1 C118T rs11615 was correlated with color restoring effect, first color restoring time, and duration of treatment (P<0.05). The higher percentage of CC genotype of ERCC1 C118T SNP showed more efficacy in skin color recovery (restoring area >50%), shortening of first restoring color time (≤1 month), shorter time treatment (≤1 month) comparing to CT+TT genotype of this site (P<0.05). XPC Lys939Gln SNP site had nothing to do with color restoring effect (P>0.05). 【Conclusion】 ERCC1 C118T SNP site is significantly related to 308nm excimer laser treatment effect. Compared to the CT+TT genotype, the CC genotype of ERCC1 C118T SNP is more efficiency in color restoring effect. The XPC Lys939Gln SNP site has little effect on laser treatment effect.
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2017, Vol. 34 
