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| Efficacy of Large-dose Atorvastatin on Emergency PCI of Stress Gyperglycemia Patients with Acute Myocardial Infarction |
| ZHU Hong-shong; LIN Zhao-feng |
| The Affiliated ChangZhen Hospital of Secomd Military Medical University,Shanghai,201199 |
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Abstract 【Objective】 To explore effects of large-dose atorvastatin on short term efficacy of emergency PCI and cardiovascular events on patients with stress hyperglycemia (SHG) acute myocardial infarction (AMI).【Methods】Sixty-eight cases of AMI with SHG were randomly divided into observation group and control group, each with 34 cases. All patients received conventional antiplatelet drugs and emergency PCI treatment. In addition, the observation group was given high dose oral atorvastatin (80mg/d, 40mg/d), while the control group was treated with conventional dose (20mg/d).The myocardial perfusion and cardiac function were compared between the two groups, and the incidence of adverse cardiovascular events in 28d was recorded in the two groups.【Results】There was no significant difference in postoperative CK-MB peak, ST segment resolution good (drop≥50%) rate, myocardial perfusion good rate of the two groups in postoperative myocardial perfusion (P>0.05); postoperative 7d LVEF in the observation group was significantly higher than that in the control group (P<0.05); the incidence of heart failure of the observation group 8.82% was significantly lower than that of the control group (29.41%) in 28d follow-up (P<0.05), there was no significant difference in incidence of severe arrhythmia, stenocardia, recurrent myocardial infarction and death in the two groups (P>0.05). 【Conclusion】 Compared with routine dose, large dose atorvastatin has obvious advantages in increasing LVEF 7d after emergency PCI and reducing incidence of 28d heart failure in AMI patients with SHG.
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Received: 28 November 2016
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2017, Vol. 34 
