脑外伤患者血清NSE、Tau、S100、MMP-9水平与脑水肿相关性的研究

doi:10.3969/j.issn.1671-7171.2017.02.039

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Abstract 【Objective】 To investigate the correlation between serum neuron specific enolase (NSE), Tau protein, S100 protein, matrix metalloproteinase 9 (MMP-9) and brain edema in patients with traumatic brain injury (TBI).【Methods】Clinical data of 96 patients with traumatic brain injury admitted in our hospital from January 2013 to November 2016 were selected and divided into observation group, and the healthy volunteers were recruited as control group in the same period of time as the control group (n = 60), the brain injury patients were evaluated by head CT examination of brain edema volume at the admission, d₃ and d₇ after admission. ELISA method was used to detect the serum NSE, Tau, S100, MMP-9 protein levels in the patients with traumatic brain injury , and all the healthy controls were tested for the same index.The serum levels of NSE, Tau, S100 and MMP-9 protein were compared between the two groups, and the correlation between the volume of brain edema and serum protein Pearson was analyzed.【Results】The serum NSE, S100 and MMP-9 in the observation group were higher than those in the control group on the day of admission, the difference was statistically significant (mean P<0.05).The serum Tau protein level in the control group was higher than that in the observation group, but the difference was not statistically significant (P>0.05).The serum NSE, Tau, S100, MMP-9 levels in the observation group were significantly positively correlated with the volume of brain edema (through CT exam) on the day of admission (mean P<0.05);The level of serum S100, MMP-9 and the volume of brain edema in admission d₃ were significantly positive (P<0.05).There was a significant positive correlation between serum S100, MMP-9 level and the value development of brain edema.【Conclusion】Serum NSE, Tau, S100 and MMP-9 could reflect the severity of brain edema in TBI, and both MMP-9 and S100 may predict the progress of brain edema, which are valuable in evaluation of the brain edema of TBI patients.

Key words： Brain Injuries Phosphopyruvate Hydratase/BL tau Proteins/BL S100 Proteins/BL Matrix Metalloproteinase 9/BL Brain Edema

Received: 19 December 2016

PACS:

R651.15

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.02.039 OR http://www.jcr.net.cn/EN/Y2017/V34/I2/327

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