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| Application of Combined Detection of Serum Human Epididymis Protein E4, CA125, and CA199 in the Diagnosis of Gynecologic Malignant Tumors |
| CHEN Rong; PENG Bi-jiang |
| Chongqing Three Gorges Central Hospital,Chongqing,404000 |
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Abstract 【Objective】To explore the application value of the combined detection of serum human epididymis protein (HE4), carbohydrate antigen 125 (CA125) and CA199 in the diagnosis of gynecologic malignant tumors. 【Methods】Forty-two patients with gynecologic malignant tumors (group A) and 42 patients with gynecologic benign tumors (group B) were selected as study subjects. All cases underwent detection of HE4, CA125 and CA199. The positive rates of the three markers and ROC were compared. 【Results】The expression levels of HE4, CA125 and CA199 individually and in combination in group A were significantly higher than those in group B (P<0.05)。The positive rate, AUC under ROC curve, accuracy, specificity and sensitivity for the detection of the combination of markers in group A were higher than those of CA125 and CA199 alone (P<0.05), but those parameters did not show significant difference compared to those of HE4 alone (P>0.05 ). However, the sensitivity of the combined detection was significantly higher than that of HE4 alone (P<0.05).【Conclusion】The value of HE4 in diagnosing gynecologic malignant tumors is higher than CA125 and CA199 alone. The combined diagnosis of the three markers can further improve the differential diagnosis rate.
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Received: 25 June 2016
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2017, Vol. 34 
