定量CT评估1型糖尿病患者股骨骨密度和骨强度

doi:10.3969/j.issn.1671-7171.2017.02.021

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Abstract 【Objective】To evaluate the bone mineral density (BMD) and bone strength of femoral bone in patients with type 1 diabetes mellitus by quantitative CT, and the relationship with insulin-like growth factor -1 (IGF-1).【Methods】Twenty-five patients with type 1 diabetes mellitus in our hospital were selected as observation group, and 25 healthy subjects in the same period of time in our hospital were selected as control group.Through the three-dimensional quantitative CT, volumetric bone mineral density (vBMD) and bone strength , serum IGF-1, bone alkaline phosphatase (B-ALP), osteocalcin (sOC) and procollagen amino terminal peptide (P I NP) at different parts of femoral bone were calculated ,and the correlation between bone mineral density and bone strength of femoral bone and IGF-1 of type I diabetes mellitus patients were analyzed .【Results】Compared with the control group, the femoral neck cortex vBMD of the observation group was significantly reduced [(582.5 ± 27.7) mg/cm³ vs (558.1± 31.9) mg/cm³,P<0.05];The total vBMD, cortical thickness and cortical cross-sectional area were significantly lower [(258.4 ± 42.9) mg/cm3 vs(223.7± 27.3)mg/cm³;(3.3 ± 0.7)mm vs(2.8 ± 0.5)mm;(5.3 ± 1.2)cm² vs (4.3 ± 0.5)cm²;mean P<0.01]. Compared with the control group, the BR of the observation group was significantly increased[(10.8 ±1.8) vs(12.9±1.9),P<0.01]; The serum levels of B-ALP, sOC, P I and NP in the observation group and the control group had no significant difference (P>0.05).There was a significant positive correlation between serum IGF-1 and total vBMD of femoral neck in patients with type 1 diabetes mellitus (r=0.48; P<0.05).【Conclusion】Quantitative CT revealed that vBMD, cortical cross-sectional area and cortical thickness were lower in patients with type 1 diabetes. Serum IGF-1 level can significantly affect the total vBMD of femoral neck in patients with type 1 diabetes mellitus.

Key words： Femur/RA Diabetes Mellitus, Type 1 Tomography, X-Ray Computed Bone Density

Received: 26 April 2016

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R587.1

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2017.02.021 OR http://www.jcr.net.cn/EN/Y2017/V34/I2/272

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