|
|
|
| Influence of Calcitriol Soft Capsules on Urine Protein of Patients with Diabetic Nephropathy |
| GUO Li-ping; HU Chun; BIAN Zhi-xiang,et al |
| Division of endocrine,Shanghai Ninth People's Hospital,Shanghai JiaoTong University School of Medicine,Shanghai,201999,China |
|
|
|
Abstract 【Objective】To study the influence of calcitriol soft capsules on urine protein of patients with diabetic nephropathy (DN). 【Methods】From January 2014 to April 2016, 86 patients with DN were chosen as study objects. All patients were divided into 2 groups: the control group and the study group. The 43 patients in the control group were treated with anti-hypertension/ hyperglycemia/ hyperlipidemia, while the 43 patients in the study group were treated with calcitriol soft capsules for 3 months in addition to anti-hypertension/ hyperglycemia/ hyperlipidemia. The effect rate, SCr, uAER, eGFR and UAlb/Cr were compared between two groups. 【Results】After treatment, the uAER, SCr and UAlb/Cr of patients in the two groups decreased significantly (P＜0.05), but the levels in the study group showed more dramatic decrease (P＜0.05). There was no significant change in eGFR before and after treatment in the two groups (P>0.05). Compared to before treatment, the systolic blood pressure (SBP), fasting blood glucose (FPG), glycosylated hemoglobin (HbA1c) and low density lipoprotein cholesterol (LDL-C) in two groups were significantly decreased (P<0.05), while 1,25(OH)2D3 and high density lipoprotein cholesterol (HDL-C) were significantly higher than those before treatment (P<0.05). After treatment, the levels of FPG and HbA1c were significantly lower in the study group than those in the control group (P<0.05), but the level of 1,25(OH)2D3 was significantly increased (P<0.05). The level of 1,25 (OH)2D3 after treatment was significantly correlated with clinical efficacy, uAER, UAlb / Cr and blood pressure (P<0.05). The effect rate of study group was 83.72%(36/43) compared to that of the control group, which was 62.79%(27/43); the difference had statistical significance (χ2=4.807,P＜0.05). 【Conclusion】Calcitriol soft capsules can help increase the kidney function of patients with DN, as well decrease the urine protein.
|
|
Received: 14 June 2016
|
|
|
|
|
|
[1] Pengchao D,Baoxia F,Huirong H,et al.NOD2 promotes renal injury by exacerbating inflammation and podocyte insulin resistance in diabetic nephropathy[J].Kidney Int,2013, 84(2):265-276.
[2] 顾金金,韩丽娜,刘强,等. ACEI与ARB联合治疗临床糖尿病肾病的疗效与安全性的Meta分析[J].中南大学学报(医学版),2013,38(6):623-630.
[3] 周晓春,陈晓.维生素D与2型糖尿病关系的研究进展[J].中国全科医学,2014,17(14):1577-1580.
[4] 李冬梅,张颖,丁波,等.血清25羟维生素D缺乏与糖尿病肾病的关系[J].中华内科杂志,2013,52(11):970-974.
[5] 丁晓静,傅晓红,刘连勇,等.超声造影定量评价糖尿病肾病肾功能损害的价值[J].中国临床医学影像杂志,2013,24(8):569-571,582.
[6] 李攻戍.从技术评价角度对合理应用《中药新药临床研究指导原则》的几点思考[J].中药新药与临床药理,2008,19(4):319-321.
[7] Yashpal S, Garg MK, Nikhil T,et al. A study of insulin resistance by HOMA-IR and its cut-off value to identify metabolic syndrome in urban Indian adolescents [J].J Clin Res Pediatr Endocrinol,2013, 5(4):245-251.
[8] Casas JP,Chua W,Loukogeorgakis S,et al. Effect of inhibitors of the renin-angiotensin system and other antihypertensive drugs on renal outcomes:Systematic review and meta-analysis[J].Lancet,2005,366(9502):2026-2033.
[9] Horst JA,Taylor KS,Stevens RJ,et al. The impact of renin angiotensin-aldosterone system inhibitors on Type 1 and Type 2 diabetic patients with and without early diabetic nephropathy[J].Kidney Int,2012,81(7):674-683.
[10] 胡勤锦,闫振成. 尿毒清联合ARB/ACEI治疗糖尿病肾病大量蛋白尿的疗效观察[J].重庆医学,2014,11(26):3436-3438.
[11] 周剑锁,张捷.维生素D临床应用研究进展[J].检验医学,2013,28(6):539-543.
[12] 郭丽萍. 活性维生素D3对糖尿病大鼠胰岛细胞功能影响的研究[J].中国医药导报,2013;10(12): 27-29.
[13] 王兴盛.糖尿病肾病与糖尿病肾病合并非糖尿病肾病的病理及临床特征分析[J].医学临床研究,2015,32(1):151-152.
[14] 徐敏,杨丽华.微炎症状态相关因子对糖尿病肾病早期的诊断意义[J].医学临床研究,2014,31(8):1575-1577.
[15] 孙晶,程劲,张金元.慢性肾脏病患者血清1,25(OH)2D3水平与蛋白尿及尿炎症细胞因子相关性研究[J].中国中西医结合肾病杂志, 2011,12( 4) : 311-314.
[16] 王媛,史慧婷,姜书宁,等.糖尿病肾病患者维生素D结合蛋白水平及影响因素研究[J].中国全科医学,2015,(31):3812-3817. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 373-375. |
|
|
|
|
2017, Vol. 34 
