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| Clinical Detection Value of Biochemical and Immune Parameters in Patients with HIV and Hepatitis B Virus Superinfection |
| SHI Zhi-ling; DAI Wei; ZHEN Hui,et al |
| The third people's Hospital of Shenzhen 518112 |
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Abstract 【Objective】To analyze the changes of biochemical and immune indexes in patients with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) superinfection. 【Methods】The subjects of this study included: 30 cases with HIV infection (HIV group), 32 cases with HBV infection (HBV group), and 20 cases with both HIV and HBV superinfection(C group). The liver function, immune function, and routine blood biochemical indexes were compared between the three groups. 【Results】①CD3+, CD4+ and CD4+/CD8+ in the HBV group were higher than those in the HIV group and C group (P<0.05), there was no significant difference in these values between the HIV group and C group (P>0.05). ②AST, ALT, and TBiL in the HBV group were higher than those in the HIV group and C group (P<0.05). There was no significant difference between the HIV group and C group (P>0.05); ③ The viral loads of HIV RNA and HBV DNA in the C group were higher than those in the HIV group (P<0.05). ④Compared to the HIV and C group, the Hb levels were higher while the levels of PLT and RBC were lower in the HBV group (P<0.05). There were no significant differences in the Hb, PLT and RBC levels between the HIV group and C group (P>0.05). 【Conclusion】A HIV / HBV superinfection may cause the body's immune function to decrease further and their condition to exacerbate, but it may actually reduce liver inflammatory injury in patients with HBV. It has no significant effect on HIV-induced anemia.
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Received: 29 November 2016
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2017, Vol. 34 
