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| Effect of Double-loop Alcohol on Inflammatory Factors, Gastrointestinal Function and Liver Function in Rats with Liver Cirrhosis |
| DONG Li; WANG Jian; JIA Chen-hong; et al |
| Department of pharmacy, Langfang People's Hospital, Langfang, 065000 |
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Abstract 【Objective】To study the effect of double loop alcohol on inflammatory factors, gastrointestinal function and liver function in rats with liver cirrhosis. 【Methods】Sixty male SD rats were selected and randomly divided into control group, model group and bicyclol low dose group, middle dose group, high dose group. The liver cirrhosis model was established by subcutaneous injection of carbon tetrachloride. Bicyclol low dose, middle dose and high dose groups were given 0.1g/kg and 0.2g/kg, 0.3 g/kg of bicyclol orally. At 8 weeks after intervention, serum was collected and serum levels of inflammatory factors (IL-1, IL-8, TNF-α), gastrointestinal mucosal barrier function indexes (PCT, LPS, D-lactate) and liver function indexes (ALT, AST) were determined. 【Results】 At 8 weeks after the intervention, serum IL-1, IL-8, TNF-α, ALT, AST, PCT, LPS, D-lactate contents of rats in the model group were significantly higher than those in the control group (t=13.729~23.179, P<0.05). Serum IL-1, IL-8, TNF-α, ALT, AST, PCT, LPS, D-lactate contents of rats in bicyclol low dose, middle dose and high dose groups were significantly lower than those of model group (t=6.324~20.938,P<0.05). As bicyclol dose increased, serum IL-1, IL-8, TNF-α, ALT, AST, PCT, LPS, D-lactate contents decreased (t=2.224~7.456,P<0.05). 【Conclusion】Double-loop alcohol has protective effect on the gastrointestinal function and liver function of liver cirrhosis model rats, and can inhibit the synthesis of inflammatory factors, which is an ideal drug for the treatment of liver cirrhosis.
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Received: 16 November 2016
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2017, Vol. 34 
