|
|
|
| Prevalence of Tc17 Cells in the Peripheral Blood of Patients with Osteosarcoma and its Clinical Significance |
| LU Ling-yun; ZHONG Yong; DAI Zhe-hao |
| Department of orthopedics, the Fifth Hospital of Xiamen. Xiamen, 361101, China |
|
|
|
Abstract 【Objective】To investigate the prevalence of Tc17 cells in the peripheral blood of patients with osteosarcoma. 【Methods】Flow cytometry was used to evaluate the prevalence of Tc17 cells in the peripheral blood of 41 patients with osteosarcoma and 17 healthy people. In addition, the concentration of IL-17 was measured. The relationship between peripheral blood Tc17 cell level with the concentration of IL-17 and tumor stage was determined statistically.【Results】The prevalence of Tc17 cells in the peripheral blood of patients with osteosarcoma (3.18±1.99%) increased greatly with increased levels of IL-17, compared with the normal control subjects (0.72±0.46%). The differences were statistically significant (P<0.01). The percentage of Tc17 cells was not associated with the concentration of IL-17 or the stages of osteosarcoma. 【Conclusion】The prevalence of Tc17 cells is increased in the peripheral blood of patients with osteosarcoma.These cells may negatively regulate antitumor immune response of patients.
|
|
Received: 12 December 2016
|
|
|
|
|
|
[1] Kager L, Zoubek A, Potschger U,et al. Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant Cooperative Osteosarcoma Study Group protocols[J].J Clin Oncol,2003, 21(10):2011-2018.
[2] Hamada H, Garcia-Hernandez Mde L, Reome JB, et al. Tc17, a unique subset of CD8 T cells that can protect against lethal influenza challenge[J].J Immunol,2009, 182(6):3469-3481.
[3] Hoinrichs CS, Kaiser A, Paulos CM, et al. Type 17 CD8+ T cells display enhanced antitumor immunity[J].Blood,2009, 114(3):596-599.
[4] Zhuang Y, Peng LS, Zhao YL, et al. CD8(+) T cells that produce interleukin-17 regulate myeloid-derived suppressor cells and are associated with survival time of patients with gastric cancer[J].Gastroenterology,2012, 143(4):951-962 e8.
[5] Shin HC, Benbernou N, Fekkar H, et al. Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway[J].Cytokine,1998 , 10(11):841-850.
[6] Tsai JP, Lee MH, Hsu SC, et al. CD4+ T cells disarm or delete cytotoxic T lymphocytes under IL-17-polarizing conditions[J].J Immunol,2012, 189(4):1671-1679.
[7] Garcia-Hernandez Mde L, Hamada H, Reome JB, et al. Adoptive transfer of tumor-specific Tc17 effector T cells controls the growth of B16 melanoma in mice[J].J Immunol,2010,184(8):4215-422. |
| [1] |
. [J]. JOURNAL OF CLINICAL RESEARCH, 2017, 34(2): 397-399. |
|
|
|
|
2017, Vol. 34 
