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| Expression of MMP-9, bcl-2, and the HSP90α Protein in Non-Small Cell Lung Cancer Tissues and its Cinical Significance |
| ZHANG Zhi-guang, REN Min, HU Yun-hai, et al |
| Department of thoracic surgery, Pixian people's Hospital, Chengdu, Sichuan 611730 |
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Abstract 【Objective】To investigate the expression of matrix metalloproteinase-9 (MMP-9), B-cell lymphoma-2 gene (bcl-2), and heat shock protein 90 alpha (HSP90α) in non-small cell lung cancer (NSCLC) tissues and its clinical significance.【Methods】The pathological tissues of 62 patients with NSCLC were collected and taken as the observation group. There were 30 cases in which the normal lung tissues were adjacent to the cancer tumors with a distance to the tumor of a margin > 3 cm. These 30 cases were determined to be the control group. The expression levels of MMP-9, bcl-2, and HSP90α in pathological tissues and cancer adjacent tissues were determined, and the correlation between the expression of each protein and clinical pathological factors was analyzed.【Results】The expression level of and positive rate of MMP-9 mRNA, bcl-2 mRNA, and HSP90α mRNA in the observation group were all higher than those in the control group (P<0.05). There were significant differences in the positive rates of MMP-9 and HSP90 protein between patients with NSCLC of different TNM stages, with or without lymph node metastasis (P<0.05). There were significant differences in the positive rates of bcl-2 protein between patients with NSCLC with different tissue types (P<0.05). 【Conclusion】The positive rates of MMP-9, bcl-2, and HSP90α in non small cell lung cancer tissues are higher than those in cancer adjacent normal tissues. Expression of MMP-9 and HSP90 is related to TNM stage and lymph node metastasis, and expression of bcl-2 protein is related to NSCLC tissue types.
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Received: 11 July 2016
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2017, Vol. 34 
