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| Clinical Significance of Concentration Detection of Gastric Juice α1-antitrypsin in Diagnosis of Gastric Cancer |
| SHI Xiang-jun, HUANG Xin-yu, WANG Yu,et al |
| Department of General Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China |
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Abstract 【Objective】To explore the clinical significance of detection of gastric juice α1-antitrypsin in diagnosis of gastric cancer.【Methods】114 patients with gastric cancer (gastric cancer group), 43 patients with benign gastric diseases (benign gastric diseases group) and 25 healthy people (control group) who underwent upper gastrointestinal endoscopic examination in our hospital from February 2011 to April 2013 were selected as research subjects. The levels of concentration of gastric juice α1-antitrypsin of these three groups were examined respectively by ELISA. The experimental and clinical data were analyzed statistically.【Results】The concentration of gastric juice α1-antitrypsin (1368.7 ± 498.4) μg/dL in gastric cancer group was significantly higher than that in the benign gastric disease group (345 ± 96.5) μg/dL and the healthy group (31.2±17.3) μg/dL, and the difference was statistically significant (P<0.05); Gastric cancer sensitivity, specificity, accuracy of gastric juice α1-antitrypsin exams were 90.4%, 89.7% and 90.1%; the α1 antitrypsin concentration of Ⅲ~Ⅳ gastric cancer patients was significantly higher than that of I ~ II patients, the difference was statistically significant (P<0.05).【Conclusion】The concentration detection of α1-antitrypsin in gastric juice can improve the accuracy in the diagnosis of gastric cancer and has great clinical value of further studying.
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Received: 24 February 2016
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[1] Parthasarathy G, Maroju NK, Kate V,et al. Serum pepsinogenⅠandⅡlevels in various gastric disorders with special reference to their use as a screening test for carcinoma stomach[J].Trop Gastroenterol,2007,28(4):166-170.
[2] 王江红, 项颖. 早期胃癌的筛查现状及诊断进展[J].重庆医学,2009, 38(20): 2634-2636.
[3] Carpelan-Holmstrom M, Louhimo J, Stenman UH, et al. CEA, CA 19-9 and CA 72-4 improve the diagnostic accuracy in gastrointestinal cancers[J].Anticancer Res,2002,22(4):2311-2316.
[4] Tocchi A ,Costa G,Lepre L ,et al. The role of serum and gastric juice levels of CEA, Cα19-9, CA72-4 in patients with gastric cancer[J].J Cancer Res Clin Oncol,1998,124(8):450-455.
[5] 郄日升,耿长新,宋学美,等. GCA、CEA、SA、ASP 联合检测胃液诊断胃癌的研究[J].新消化病学杂志,1996,4(2) :71-73.
[6] Takahashi Y,Takeuchi T,Sakamoto J, et al. The usefulness of CEA and/or Cα19-9 in monitoring for recurrence in gastric cancer patients:a prospective clinical study[J].Gastric Cancer,2003,6(3):142-145.
[7] 曾雪萍,詹晓文,刘敦菊,等.胃液中Cα19-9 、CA72-4 、CEA 检测对胃癌诊断价值的探讨[J].实用临床医学,2006,7(10):8-10.
[8] Hsu PI, Chen CH, Hsieh CS, et al. α1-antitrypsin precursor in gastric juice is a novel biomarker for gastric cancer and ulcer[J].Clin Cancer Res,2007,13(3): 876-883.
[9] Hsu PI,Chen CH,Hsiao M,et al.Diagnosis of gastric malignancy using gastric juice alphα1-antitrypsin[J].Cancer Epidemiol Biomarkers Prev,2010,19(2):405-411.
[10] Janciauskiene S. Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophiological roles[J].Biochim Biophys Acta,2001,1535(3):221-235.
[11] Kataoka H, Uchino H, Iwamura T, et al. Enhanced tumor growth and invasiveness in vivo by a carboxyl-terminal fragment of α1 proteinase inhibtor generated by matrix metalloproteinase: a possible modulatory role in natural killer cytotoxicity [J].Am J Pathol,1999,154(2):457-468.
[12] Tahara E, Ito H, Taniyama K, et al. Alpha 1-antitrypsin, alphα1- antichymotrypsin, and alpha 2-macroglobulin in human gastric carcinomas: a retrospective immunohistochemical study[J].Human Pathol,1984, 15(10): 957-964.
[13] Zelvyte I, Sjogren HO, Janciauskiene S. Effects of native and cleaved forms of α1-antitrypsin on ME 1477 tumor cell functional activity[J].Cancer Detect Prev,2002,26(4):256-265.
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2017, Vol. 34 
