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| Expression of BRAC-1 and RAD51 in Esophageal Squamous Cell Carcinoma and its Clinical Significance |
| TIAN Yun-xiao, YUAN Yan-long, SUN Ying,et al |
| Handan Central Hospital Hebei Handan, 056001 |
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Abstract 【Objective】To determine the expression of BRCA1 and RAD51 in the esophageal squamous cell carcinoma(ESCC)and its significance. 【Methods】The expression of BRCA1 and RAD51 in 120 cases of esophageal squamous cell carcinoma and adjacent normal tissues and 60 cases of intraepithelial neoplasia were detected by SP immunohistochemical method.The relationship between the positive expression of BRCA1 and RAD51 and clinicopathological features was analyzed and compared, and the prognostic factors of esophageal squamous cell carcinoma were analyzed by COX regression analysis.【Results】The positive expression of BRCA1 in esophageal squamous cell carcinoma was mainly localized in cytoplasm, and the positive expression of BRCA1 was significantly higher than that of intraepithelial neoplasia and adjacent normal tissues (P<0.05). The positive expression in esophageal squamous cell carcinoma was located in the nucleus, and the positive expression of RAD51 was significantly higher than that of epithelial and normal esophageal mucosa tissues(P<0.05). Correlation analysis showed that the expression of BRCA1 was positively correlated with the expression of RAD51 in esophageal squamous cell carcinoma (P<0.05). Lymph node metastasis and RAD51 are the main factors affecting the prognosis of patients with esophageal squamous cell carcinoma.【Conclusion】The positive expression of BRCA1 and RAD51 in esophageal squamous cell carcinoma is associated with poor prognosis, which is expected to be a new biomarker for evaluating the biological behavior of esophageal squamous cell carcinoma.
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Received: 04 February 2016
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Corresponding Authors:
ZHAO Fei
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| About author:: ZhaoFei (1984 -), female, graduate students |
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2017, Vol. 34 
