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| Study on Airway Inflammation Phenotypes and Clinical Features in Asthmatic Patients |
| LI Wen-bi |
| Respiratory Medicine, China People's Liberation Army 324 Hospital,ChongQing, 400020 |
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Abstract 【Objective】To analyze the airway inflammation phenotypes and clinical features of severe asthma compared to mild-moderate ("common") asthma. 【Methods】A total of 417 cases of asthma were retrospectively analyzed in our hospital from January 2012 to August 2015. Out of these, 43 patients were classified as the severe asthma group, and 374 patients as the common asthma group. All patients received induced sputum cell counts and pulmonary function tests, and all received fractional exhaled nitric oxide (FENO) tests. The airway inflammation phenotypes were defined and the clinical features of patients with severe asthma were studied. 【Results】①Age, BMI, weight, and induced sputum neutrophil of the two groups had no statistical significance (P>0.05). Differences in FEV1/FVC, induced sputum acidophilic granulocyte and FENO of the two groups were statistically significant (P<0.05). ② There were no differences between the severe asthma group and the common asthma group in the distributions (P>0.05). The distribution of airway inflammation phenotypes of asthma was as follows: eosinophilic subtype, mixed granulocytic subtype, neutrophilic subtype, and paucigranulocytic subtype. ③ FENO, FEV1/FVC(%) and FEV1 had significant statistical difference (P<0.05) in severe asthmatic patients with different airway inflammatory phenotypes, and the neutrophil type was the most severe type of severe asthma with lung function damage. 【Conclusion】Eosinophilic subtype is the most common airway inflammatory phenotypes of asthma. Neutrophilic subtype may be the most intractable subtype with severely damaged pulmonary function in severe asthma.
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Received: 10 October 2015
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2016, Vol. 33 
