原发性高血压患者血清前蛋白转化酶枯草溶菌素9与颈动脉粥样硬化的相关性研究

doi:10.3969/j.issn.1671-7171.2016.11.012

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Abstract 【Objective】 To investigate the correlation between serum proprotein convertase subtilisin/kexin type 9 (PCSK9) and carotid atherosclerosis in primary hypertension patients. 【Methods】 320 primary hypertension patients were divided into non-carotid atherosclerosis (NCAS) group and carotid atherosclerosis (CAS) group according to CIMT. Body mass index(BMI), blood pressure, blood glucose, blood lipid and serum PCSK9 were measured. logistic multiple regression was used to analyze the correlative factors of serum PCSK-9 level and CIMT .【Results】 The levels of serum PCSK-9 in the CAS group (366.9±72.3) mg/L were significantly higher than that of the NCAS group (280.2±61.4) mg/L. The difference was statistically significant (P<0.05). Logistic multivariate regression analysis revealed that serum PCSK9 was the independent risk factor of carotid atherosclerosis in primary hypertension patients.【Conclusion】The level of serum PCSK-9 is positively correlated with CIMT in patients with primary hypertension, it could be an independent risk factor for atherosclerotic disease.

Key words： Proprotein Convertases Hypertension/BL Atherosclerosis Carotid Arteries Risk Factors

Received: 07 July 2016

PACS:

R544.1

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http://www.jcr.net.cn/EN/10.3969/j.issn.1671-7171.2016.11.012 OR http://www.jcr.net.cn/EN/Y2016/V33/I11/2116

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