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| Clinical Study of Glutamine on Neonatal HIE |
| LEI Juan-juan |
| Department of Pediatrics, Yanan Affiliated Hospital of Yan'an University, Yan'an Shan'xi,716000 China |
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Abstract 【Objective】To study the protection effect of glutamine on cerebral hypoxia of neonates.【Methods】Eighty neonates in our hospital with HIE from May 2014 to February 2015 were chosen as study objects, all neonates were divided into the treatment group(Group A) and the control group . According to the different dosage ,the former was re-divided into three sub-groups : A1[ glutamine 50mg/(kg·d)], A2[glutamine 75mg/(kg·d)] and A3 [glutamine 100mg/(kg·d)], 20 cases in each. The treatment effect , the Neonatal Behavioral Neurological Assessment (NABA)before and after treatment, the Neuroglobin (NGB) and the neuron-specific enolase(NSE)were compared among different groups.【Results】The effect rate of group A1 was 65.00%, A2 was 75.00%, A3 was 90.00%, the Group B was 50.00%, the difference had statistical significance(P＜0.05). After treatment, the NABA scores of different groups were increased significantly(P＜0.05), and the NABA had significant difference among different groups(P＜0.05). Before treatment, NGB and NSE had no significant difference among different groups(P＞0.05); 3d and 7d after the treatment, the NGB and NSE of neonates with HIE decreased significantly(P＜0.05), and the NGB and NSE after treatment had significant difference among the groups statistically(P＜0.05). The dose of 100 mg/ (kg·d) glutamine had the best clinical efficacy.【Conclusion】Glutamine can improve the stability of the membrane of neurons, which can protect the brain from hypoxia, the dose of 100 mg/ (kg·d) glutamine has the best clinical efficacy.
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Received: 14 October 2015
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2016, Vol. 33 
