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| Analysis of Protective Effect of Trimetazidine on Renal Function in Hypertensive Patients with Coronary Heart Disease |
| ZHANG Yi-ping |
| Department of Pharmacy , the Chongqing Xinqiao Hospital, Chongqing 400038 |
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Abstract 【Objective】 To investigate the protective effect of Trimetazidine on renal function in hypertensive patients with coronary heart disease. 【Methods】Eighty-six cases of hypertension with coronary heart disease were randomly divided into two groups, each of 43 cases. The control group was treated with routine therapy; while on the basis the control group, the observation group was treated with Trimetazidine. One course of treatment for 4weeks, 3 courses were intervened. Blood pressure, heart function and renal function and adverse reaction conditions were compared between the two groups before and after treatment.【Results】After treatment, DBP, SBP levels, LVEDD, LVESD, SCr one week after treatment, BUN, Cys C, hs-CRP and IL-6 levels in the two groups were significantly decreased than those before treatment while LVEF was significantly increased than that before treatment (P<0.05). 3 courses after the treatment, LVEDD, LVESD, LVEF, SCr one week after treatment, BUN, Cys C, hs-CRP, IL-6 and NO levels in the observation group were significantly improved than those in the control group (P<0.05). There were no significant differences in the incidence of adverse reactions between the two groups (P>0.05). 【Conclusion】 Trimetazidine can significantly improve the cardiac function in hypertensive patients with coronary heart disease. It has also protective effect on renal function. This may be related to the drug functions of inflammation reduction and vascular endothelium improvement.
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Received: 05 May 2016
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[1] 徐忠,孙卫东,吕更,等.曲美他嗪对高血压病患者心脏重构及心房颤动的影响[J].山东医药,2012,52(41):49-51.
[2] 苗永国,陈洪涛.稳心颗粒联合曲美他嗪治疗慢性心力衰竭的临床研究[J].现代药物与临床,2015,30(5):547-550.
[4] 周利平,朱斌,郑翼,等.曲美他嗪治疗冠心病心功能不全的临床研究[J].现代药物与临床,2014,29(11):1245-1248.
[5] 王一然,郑宇,王悦喜,等.老年冠心病患者冠状动脉介入治疗前阿托伐他汀联用曲美他嗪对肾功能的影响[J].中华老年心脑血管病杂志,2015,17(6):580-582.
[6] Seeliner E,Sendeski M,Rihal CS,et al.Contrast-induced kidney injury:mechanisms,risk factors,and prevention[J].Eur Heart J,2012,33(16):2007-2015.
[7] 侯聪聪,李拥军,张辉,等.负荷量曲美他嗪对冠心病合并原发性高血压患者内皮功能的影响[J].临床荟萃,2011,26(2):110-112,116.
[8] 杨卫红.血浆内皮功能标志物在心脑血管病中的意义[J].国际脑血管病杂志,2009,17(3):200-204.
[9] 杜艺,钱白音,魏玉婷,等.盐酸曲美他嗪预处理对大鼠肾脏急性缺血再灌注损伤的影响[J].山东医药,2015,55(29):23-25. |
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2016, Vol. 33 
