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| Application Value of Fibroscan Combined with APRI in the Diagnosis of Cirrhosis Portal Hypertensive Gastropathy |
| ZHAO Zhi, ZHANG Bao-hua, LIU Xiao-li |
| Hunan Provincial Hospital of Chinese Armed Police Corps, Changsha ,410006 |
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Abstract 【Objective】To study the relationship between Fibroscan, aspartate aminotransferase to platelet ratio index (APRI), and cirrhosis portal hypertensive gastropathy (PHG) and analyze the clinical significance of combined detection of the two methods in the diagnosis of PHG. 【Methods】A total of 116 cases of hepatitis B infection-related liver cirrhosis were detected for liver stiffness measurement (LSM), APRI, degree of esophageal varices (EV), portal vein diameter (PVD), platelet count/spleen diameter (PC/SD), and PHG. The relationships between LSM, APRI and EV, PVD, and PC/SD were analyzed and the differences of LSM and APRI were compared in varying degrees of PHG patients. Then, the receiver operating characteristic curves (ROC) of LSM and APRI were drawn to diagnose PHG. 【Results】The differences were statistically significant for LSM and APRI in varying degrees of EV. LSM and APRI have correlation with PVD and PC/SD. Also, LSM and APRI in patients with varying degrees of PHG were statistically significant. AUROC of Fibroscan for PHG was 0.80(0.71~0.89, the sensitivity was 78.91%, and the specificity was 73.08%. The AUROC of APRI for PHG was 0.80(0.70~0.90), the sensitivity was 65.83%,and the specificity was 92.27%. The AUROC of the combined method for PHG was 0.95(0.89~1.00), the sensitivity was 86.77%,and the specificity was 98.10%. 【Conclusion】FibroScan and APRI reflected the degree of portal hypertension and PHG in liver cirrhosis patients. The combined detection of the two methods was more helpful to improve the accuracy of diagnosis, and it had certain clinical value for the noninvasive diagnosis of PHG.
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2016, Vol. 33 
