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| Study on Blood Purification Scheme in Patients with Acute Decompensated Heart Failure Secondary to Type 1 Cardiorenal Syndrome |
| CHEN Dong-ying, LI Zhi-liang |
| Department of Cardiology, Zhujiang Hospital of Southem Medical University, Guangzhou 510282,China |
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Abstract 【Objective】 To investigate the blood purification scheme in patients with acute decompensated heart failure(ADHF) secondary to Type 1 cardiorenal syndrome (CRS).【Methods】 One hundred and ninety-six patients with acute decompensated heart failure(ADHF) secondary to Type 1 cardiorenal syndrome (CRS) admitted by the Department of Cardiology and the Department of Renal Medicine in our hospital were selected from February 2012 to February 2015. According to different blood purification scheme they were divided into 4 groups: group A (n=40, pure ultrafiltration solution), group B (n=42, slow continuous ultrafiltration), group C (n=52, intermittent hemodialysis) and group D(n=62, continuous venovenous hemofiltration, CVVH). Serum urea (Urea), creatinine (SCr), B type natriuretic peptide (BNP), cardiac troponin I (cTn-I), left ventricular end diastolic diameter (LDV), cardiac output (CO), left ventricular ejection fraction (LVEF) and central venous pressure (CVP) of patients were detected before and after treatment .【Results】Before treatment, the difference of comparison in serum Urea, SCr, BNP, cTn-I of the four groups of patients was not statistically significant (mean P>0.05); After treatment, levels of the serum Urea, SCr, BNP and cTn-I in the four groups were lower than those before treatment (except for the cTn-I level in the Group A), and the difference was statistically significant (mean P<0.05); After treatment, the differences between the groups were statistically significant (mean P<0.05). In comparison of LDV, CO, LVEF, CVP of the four groups of patients before treatment , the difference was not statistically significant (mean P>0.05); After treatment, CVP, LDV of the four groups of patients were lower than those before treatment, and LVEF, CO were higher than those before treatment, and the differences between the groups were statistically significant (mean P<0.05).【Conclusion】The adoption of continuous venovenous hemofiltration (CVVH) for blood purification in patients with acute decompensated heart failure(ADHF) secondary to Type 1 cardiorenal syndrome (CRS) is of high security with good curative effect ; Slow continuous ultrafiltration and intermittent hemodialysis have similar effects in terms of safety and efficacy; And the safety and efficacy of ultrafiltration alone is not satisfactory.
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Received: 25 April 2016
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2016, Vol. 33 
