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| Serum Tartrate-Resistant Acid Phosphatase 5b (TRACP 5b) and Carboxyterminal Cross-Linked Telopeptide of Type I Collagen (ICTP) in the Diagnosis of Bone Metastasis of Breast Cancer |
| PEI Lei, TANG Zhang-hua |
| Department of Surgery, Second Hospital of Xiangya, Central South University, Changsha,410010 |
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Abstract 【Objective】To study the clinical significance of serum tartrate-resistant acid phosphatase 5b (TRACP 5b) and carboxyterminal cross-linked telopeptide of type I collagen (ICTP) in diagnosing bone metastasis of breast cancer. 【Methods】A total of 714 patients in the Breast and Thyroid Department of the Second Xiangya Hospital were included in this study and were divided into two groups based on the occurrence of bone metastasis. The bone metastasis group had 74 patients and the non-bone metastasis group had 640 patients. Serum ICTP and TRACP 5b were measured by using the ELISA method. The cut-off values were calculated using the receiver operating characteristic curve (ROC) method, and the sensitivity and specificity of each serological diagnostic method were compared. 【Results】The levels of serum ICTP and TRACP 5b were higher in the bone metastasis group than in the non-bone metastasis group with statistical significance (P<0.01). The cut-off values of serum ICTP and TRACP 5b were 5.2μg/L and 5.6 U/L, respectively. Sensitivity was 81.1% and 74.3%, and specificity was 89.4% and 90.8%, respectively. The sensitivity and specificity of the combined diagnosis was 93.2% and 88.0%, respectively, and was higher than the diagnosis using either solely ICTP or TRACP 5b. 【Conclusion】Serum ICTP and TRACP 5b are important biomarkers for the diagnosis of bone metastasis in breast cancer. Combination of the two biomarkers provides very meaningful for the diagnosis.
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2016, Vol. 33 
