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| Prophylactic Effect of Methylprednisolone Combined with Tropisetron on Patients at High Risk for Postoperative Nausea and Vomiting after Thyroid Surgery |
LI Yun, ZHAO Nan, FANG Bo
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| Department of Anesthesia, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China |
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Abstract 【Objective】To explore the prophylactic effect of methylprednisolone combined with tropisetron on patients at high risk for postoperative nausea and vomiting (PONV) after thyroid surgery. 【Method】 A total 120 patients at high risk for postoperative nausea and vomiting scheduled for radical operation of thyroid carcinoma were randomly divided into four groups with 30 cases in each. At 15 min before end of the operations, patients in the four groups of the patients were intravenously injected methylprednisolone 40 mg plus tropisetron 5 mg (group MT), methylprednisolone 40 mg (group M), tropisetron 5 mg (group T), and normal saline (group C). Incidence and severity of nausea and vomiting were recorded within 48 hours after surgery, and the visual analogue scale (VAS) score was used to calculate the severity of PONV.【Results】There were no significant differences in age, body weight, or operation time amongst the four groups (P＞0.05). Compared to groups C and T, the incidences of PONV during T0~2 h and T2 h~6 h and VAS score at T2 h and T6 h were significantly lower (P＜0.05). Compared to group C, the incidence of headache in group MT was significantly lower (P＜0.05), but the incidences of dizziness, anxiety, and hyperglycemia showed no obvious changes (P＞0.05).【Conclusion】Methylprednisolone combined with tropisetron has significant preventative effect on patients at high risk for PONV and the adverse reactions do not increase.
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Received: 19 June 2016
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2016, Vol. 33 
