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| Effect of Whole Brain Radiotherapy on Cognitive Function and Prospective Memory in Patients with Brain Metastases |
| HU Chan-chan, LIAN Xiang-rao, WANG Rui |
| Department of Oncology, Affiliated Hospital of Chengde Medical College,ChengDe,HeBei, 067000 |
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Abstract 【Objective】 To explore the effect of whole brain radiotherapy on the cognitive function and prospective memory in patients with brain metastases.【Methods】 A total of 100 patients underwent whole brain radiotherapy for brain metastases(WBRT) admitted in the hospital from April 2010 to May 2015 were selected. In 1 week before the whole brain radiotherapy, 1 week and 1~6 months after radiotherapy, the overall cognitive function included mini-mental state Examination (MMSE), Vocabulary fluency test (VFT), digit span test (DS) and the prospective memory including event-based prospective memory (EBPM) and event-based prospective memory (TBPM ) were assessed and compared.【Results】 One week after the radiotherapy, MMSE, DS, VFT and EBPM were all significantly lower than those before radiotherapy , and the difference was statistically significant (t=3.033,11.294, 5.055, 3.966,P<0.05); 1 week after radiotherapy, TBPM had no significant change after radiotherapy(P>0.05); MMSE and EBPM were significantly lower than the baseline in patients without neurological symptoms before radiotherapy(P<0.05), 4 months after radiotherapy , their MMSE and EBPM went to valley, and then gradually picked up, Patients with neurological symptoms before radiotherapy (MMSE≤ 26), MMSE and EBPM were significantly higher than the baseline level after radiotherapy (P<0.05), 4 months after radiotherapy, they went to the peak, then gradually decreased.【Conclusion】Whole brain radiotherapy has a certain effect on the overall cognitive function and prospective memory in patients with brain metastases, especially on those event-based prospective memory . The cognitive impairment was more significant in 4 months after radiotherapy. Patients of metastatic brain cancer with neurological system symptoms before radiotherapy may meet single separation phenomenon in the change of cognitive function after radiotherapy.
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Received: 04 July 2016
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. [J]. JOURNAL OF CLINICAL RESEARCH, 2016, 33(10): 2023-2025. |
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2016, Vol. 33 
