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| Clinical Value of AntiCyclic Citrullinated Peptide Antibodies Detection in Patients with Primary Sjogren's Syndrome |
| Department of Clinical Laboratory, Yan 'an Hospital Affiliated to Kunming Medical University, Kunming 650051, China |
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Abstract 【Objective】To investigate the clinical application of anticyclic citrullinated peptide (CCP)antibodies detection in the development and prognosis of primary Sjogren's syndrome (PSS) . 【Methods】Clinical data and laboratory related indicators of 85 patients with PSS had been analyzed statistically. 【Results】 Anti CCP antibody presented 16.47% positive (14/85 cases) and 83.53% negative (71/85 cases); the difference of the specificity of anti CCP antibody in positive and negative patients, the positive rate of autoantibodies (SSA, SSB and total antibody ANA) and levels of ESR, CRP , IgA, IgG, IgM and RFIgM was not statistically significant (P>0.05); and the difference between the occurrence of joint pain and the incidence of erosive arthritis was statistically significant (P<0.05). 【Conclusion】 In PSS patients, the anti CCP antibody positive may be related to the occurrence of joint pain and erosive arthritis ; Higher anti CCP antibody levels are more likely to lead to the development of RA in patients with PSS.
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Received: 24 July 2015
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2016, Vol. 33 
