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| Exploration of HDAC2 in the Pathogenesis of Osteoarthritis |
| Dept. of Orthopedics,People's Hospital of Longgang,Shenzhen 518000 |
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Abstract 【Objective】To investigate the possible biological roles of HDAC2, IL1β, and NO in the pathogenesis of osteoarthritis, and to understand the possible correlation of HDAC2 with IL1β, and NO with HDAC2. 【Methods】 ELISA was used to determine the amount of HDAC2 and IL1 beta ,and the method of nitrate reduction was detected the amount of NO in the synovial fluid of 51 patients with osteoarthritis (observation group). The results were compared with corresponding levels of HDAC2, IL1, and NO in 26 normal patients (control group). In addition, the relationships of HDAC2 with IL1 beta and HDAC2 with NO were explored. 【Results】The levels of HDAC2, IL1, and NO in the synovial fluids of the patients were higher in the experimental (observation) group than in the control group, with the differences beingstatistically significant (P<0.01). Using Spearman correlation analysis, it was found that for HDAC2 with IL1 beta and NO, the correlation coefficients were r=0.872 and 0.824,respectively (P<0.01); all indicators were positively correlated. 【Conclusion】HDAC2 may be a chemokine of inflammatory cytokines IL1 and NO, which can promote the formation of local noninfective inflammation of osteoarthritis.
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Received: 12 October 2015
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2016, Vol. 33 
