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Abstract 【Objective】 To investigate the correlation of plasma brain natriuretic peptide (BNP) and highsensitivity Creactive protein (hsCRP) levels with heart failure correlation in chronic renal failure patients. 【Methods】Cases were divided into patients with heart failure and chronic renal failure (A group), patients with chronic renal failure (group B), and healthy subjects (group C), with 30 cases in each group. Plasma levels of hsCRP and BNP were observed of each case, and color Doppler ultrasound measured left ventricular ejection fraction (LVEF), left ventricular end systolic diameter (LVESD), left ventricular enddiastolic diameter (LVEDD). The parallel correlations were analyzed. 【Results】BNP and hsCRP levels in groups A and B were higher than in group C; the differences were statistically significant (P<0.05). In addition, BNP and hsCRP levels in group A were higher than in group B; the difference was statistically significant (P<0.05). LVESD and LVEDD levels were significantly higher in group A than in groups B and C, while LVEF level in group A was significantly lower than that in groups B and C (P<0.05). The detectable levels of BNP and hsCRP in chronic renal failure patients were positively correlated, and both were positively correlated with LVESD and LVEDD levels. However, they were negatively correlated with LVEF; the differences were statistically significant (P<0.05). 【Conclusion】BNP and hsCRP levels were significantly increased in chronic renal failure patients with heart failure. Detection of BNP and hsCRP levels has certain significance in the diagnosis and prognosis of the disease in patients.
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Received: 17 March 2016
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2016, Vol. 33 
