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| Clinic Differences in Premedication of anesthesia of Oral Midazolamor and of Intranasal Dexmedetomidine in Children Undergoing Selective Congenital Heart Surgery |
| The Department of Anaesthesiology of Shanghai Chlidren’s Medical Center,Shanghai, 200127 |
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Abstract 【Objectives】 To investigate the clinic effects and differences of premedication of anesthesia of oral midazolamor and of intranasal dexmedetomidine in children undergoing selective congenital heart surgery. 【Methods】Two hundreds children scheduled for selective congenital heart surgery were randomly assigned to one of four groups. Group M0.5 and group M0.75 received 0.5 mg/kg or 0.75 mg/kg of oral midazolam syrup, respectively. Group D1 and group D2 received 1μg/kg or 2μg/kg of intranasal dexmedetomidine, respectively. HR, RR, PETCO2, SpO2 and Ramsay scores were recorded every 5 minutes after induction. 【Results】 The Ramsay scores of children in Groups D1 and D2 were significantly higher than those of children in Groups M0.5 and M0.75 from 10 min. after administration to induction. SpO2 in the four groups increased after administration (P=0.03,P<0.01), but showed no significant differences in levels among the four groups. Compared to a baseline, RR at 20 min. after drug administration increased significantly in both groups M0.5 and M0.75. At the same time, PETCO2 in group D2 increased significantly. However, PETCO2 in all groups remained normal.【Conclusions】By monitoring vital signs, dexmedetomidine or midazolam premedication can be safely used in children with congenital heart disease. However, dexmedetomidine 2μg/kg administered by intranasal should be used cautiously because of its influence on HR and PETCO2.
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Received: 18 January 2016
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2016, Vol. 33 
