【Objective】 To evaluate the effects of inhaling budesonide after extubation and parecoxib injection on the prevention and treatment of postoperative sore throat (POST) after tracheal intubation with a doublelumen endobronchial tube in thoracic surgery patients. 【Methods】One hundred and sixty patients aged 18~64  scheduled for elective thoracic surgery under general anesthesia were randomly divided into four groups equally with 40 patients each group. Patients in group C received no inhalation treatment. Patients in group B inhaled 1mg budesonide 30 minutes after extubation, patients in group P received a 40 mg parecoxib injection of sodium 30 minutes before postoperation, and patients in group BP inhaled 1mg budesonide and received a 40 mg parecoxib injection of sodium with a double_lumen endobronchial tube. The incidence and VAS score of POST at 1h，6h and 24h in the postoperative period after tracheal extubation were assessed. 【Results】 There was no statistical significance of patients' age, sex ratio, height, weight, time of operation, or intubation (P>0.05). The incidence and VAS scores of POST were significantly lower in group B，group P, and group BP than those of group C (P<0.05)，and lower in group BP than in group B and group P (P<0.05) after removal of endotracheal tube on a three point scale. No adverse reactions of inhalation of atomization and parecoxib sodium injection occured in any group. 【Conclusion】 The combination of budesonide and parecoxib sodium is safe and can reduce the incidence and VAS score of POST after tracheal intubation with a doublelumen endobronchial tube.