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| Analysis of the Postoperative Hypopituitarism in Pituitary Adenomas after Endoscopic TransSphenoidal Microsurgery |
| Department of Neurosurgery, Xinhua Hospital of Dalian University, Dalian Liaoning 116000,China |
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Abstract 【Objective】 To investigate the change in the hormonal level of the pituitary adenomas resected by the endoscopic transsphenoidal microsurgery, to evaluate the postoperative damaging factors of pituitary function, and to guide hormonal replacement therapy. 【Methods】We retrospectively analyzed the clinical data and therapeutic methods of 82 cases of obtained pituitary adenomas. The determinations of the hormonal level preoperative and 3d postoperative were detected. These results suggested hypopituitarism and were statistically analyzed. 【Results】The pituitary hormone levels, including thyroid hormone, corticosteroid, and prolactin, were lower 3 days postoperatively in all patients (P<0.05). Hypopituitarism was found in 34 cases and accounted for 41.4% of the total 82 patients, including 2 cases of microadenomas (12 cases, 2.4%), 22 cases of macroadenomas and giant adenomas (70 cases, 16.7%), and 16 cases of nonfunctional adenomas (45 cases, 35.5%). Results showed that decreased function or hypopituitarism before operation was more commonly found in elder patients.【Conclusion】The surgical operation could effectively reduce the hormonal level for pituitary adenomas. The ratio of hypopituitarism postoperatively is wellrelated to tumor volume. Hypopituitarism postoperation is more likely to occur in elder patients or cases which had hypopituitarism before operation or nonfunctional adenomas. Reasonable hormone replacement therapy for patient's recovery is necessary.
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Received: 11 December 2015
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2016, Vol. 33 
