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| HBVDNA Load Testing of Newborns with Intrauterine HBV Infection Prediction Value Analysis |
| Department of Neonatology, The Hospital of Yangling demonstration zone in Xi'an City Shaanxi Province, Xi'an, 712100,China |
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Abstract 【Objective】To investigate the effect of hepatitis B virus intrauterine infection on neonatal infants. 【Methods】One hundred and six cases of pregnant women with HBsAg positive results in our hospital from Jan. 2010 to Dec. 2014 were used as an observation group. According to HBV Casset results, 106 cases of pregnant women were divided into a HBsAg, HBeAg, and HBcAb positive group (26 cases), a HBsAg, HBeAb, and HBcAb positive group (74 cases) and a HBsAg, HBcAb positive group (6 cases). Venous blood of pregnant women and cord blood of infants were collected to determine HBV 5 tests and HBV DNA quantification test. 【Results】Ten infants were found to be HBsAg positive among 106 cases of pregnant women with HBsAg positive results, accounting for 9.43% of the patients. There were no significant differences among the intrauterine infection rates of the 3 groups (F=1.204,P=0.163). However, there were significant differences among the groups' HBV DNA capacities (F=5.204,P<0.05). Furthermore, HBV DNA copy and intrauterine infection was positively corelated (r=0.672,P=0.015). 【Conclusion】Using HBV serum landmarks for intrauterine infection detecting is not suitable. Thus, detecting the serum HBV DNA copy of pregnant women will help decrease the risk of intrauterine infection.
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Received: 18 May 2015
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2015, Vol. 32 
