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Abstract 【Objective】To investigate the expression and clinical significance of CD147 protein in human prostate cancer and benign prostatic hyperplasia tissues. 【Methods】 The immunohistochemical SP method was used to detect the expression of CD147 protein in 56 patients of prostate cancer tissues and 22 patients of benign prostatic hyperplasia tissues so as To analyze the correlation between CD147 protein and the clinical biological characteristics of prostate cancer. 【Results】The positive rate of CD147 protein in the observation group was 9.1%, which was significantly higher than that in the control group , the difference was statistically significant (P<0.01). There was no significant difference in CD147 protein expression in different age groups (P>0.05). The positive expression of CD147 protein in different stages of Gleason staging and pathological grading was significantly different (P<0.05), The positive expression rate of CD147 protein in each grade group was statistically significant (P<0.05). 【Conclusions】 The high expression of CD147 in prostate cancer tissues is related to its pathological stage and clinical stage. CD147 has the potential to be an important indicator to judge the invasion of prostate cancer, and to block the expression of CD147 may become a new target for the treatment of prostate cancer.
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Received: 24 December 2014
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2015, Vol. 32 
