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| Expression of Neutrophil Surface Ahesion Molecule Lymphocyte Function Associated Antigen 1 in Patients with the Preeclampsia Disease |
| People's Hospital of Longhua New District, Shenzhen, Guangdong, 518109 |
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Abstract 【Objective】The purpose of this study is to examine the expression of the neutrophil surface adhesion molecule lymphocyte function associated antigen 1（LFA1） and its relationship with preeclampsia disease (PE) patients. 【Methods】Between June 2012 and June 2014, 50 patients with PE were selected as subjects for a research project. These patients were divided into two groups in accordance with their specific medical condition: the severe PE group (20 cases), and the mild PE group (30 cases). During the duration of the experiment, 40 healthy pregnant women were selected as normal control group. The mother's blood and the blood in the umbilical cord were both found to contain neutrophils and neutrophil surface adhesion molecules FLA1 expression. Correlation analysis wasconducted. 【Results】The neutrophil count and neutrophil surfaceadhesion molecule LFA1 positive rate in the blood of the PE group mothers was found to be higher than the control group, with the difference being quite statistically significant (P<0.05). It was also found that as the PE illness aggravated, both the maternal bloodneutrophil count and neutrophil surfaceadhesion molecule LFA1 positive rate showed an increasing trend (P<0.05). In addition, maternal blood neutrophil count, neutrophil surface adhesion molecules LFA1 positive rate in the gestational diabetes group were higher than that of group without gestational diabetes, and the difference was statistically significant (P<0.05); In another analysis of the PE group , the umbilical cord blood neutrophil count and neutrophil surface adhesion molecules LFA1 positive rate were also higher than the control group, with the difference being statistically significant once again (P<0.05), and as the PE illness aggravated, both umbilical cord blood neutrophil count as well as neutrophil surface adhesion molecules LFA1 positive rate showed a trend of increased (P<0.05); Mother blood neutrophils surface expression of adhesion molecules LFA1 positive rate showed a trend of increased positively correlated with systolic blood pressure in patients with PE (r=0.597,P=0.597). Results showed that a mother's bloodneutrophil surface expression of adhesion molecules (LFA1) positive rate directly correlated with the systolic blood pressure in patients with PE (r=0.597,P=0.597), the diastolic blood pressure also showed a direct correlation (r= 0.526,P=0.526). 【Conclusion】Excessive neutrophil activation in patients with PEas well as excessive neutrophil activation is associated with PE severity. From our findings, we can now inhibit the excessive activation of neutrophils in PE pregnancy cases in complications such as prevention and control.
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Received: 06 August 2015
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2015, Vol. 32 
