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Abstract 【Objective】To investigate the clinical significance of HE4 protein and cancer antigen125（CA125）in ovarian cancer ascites．【Methods】51 cases of epithelial ovarian cancer (the ovarian cancer group), 21 cases of the ovarian borderline tumor group and 15 cases of the control group (including 2 cases of tuberculous peritonitis, 2 cases of liver cirrhosis, 11 cases of acute and chronic pelvic inflammatory disease)were selected.ELISA and radioimmunity method were used to detect ascites, serum HE4 and CA125 protein expression.【Results】The positive rates of HE4 protein in ascites and serum of the ovarian borderline tumor group and the ovarian cancer group were significantly higher in than that in the control group（P<0.05）．In ovarian cancer of different histological types, the positive expression of ascites in the endometrium ,the serous carcinoma and HE4 was significantly increased. In the early stage (Ⅰ/Ⅱ)of ovarian cancer, the sensitivity of HE4 in serum was significantly higher than that of CA125 (P<0.05). In ovarian cancer, the specificity of ascites and serum HE4 was 100%, which was significantly higher than that of CA125 (P<0.05).【Conclusions】Increased protein expression of HE4 were closely associated with tumorigenesis and pathological behaviors of ovarian cancer, which may be used as specific tumor markers to predict the earlier ovarian cancer．Combination of HE4 and CA125 measurement in ascites has an higher diagnostic value in differentiate ovarian benign and malignant tumors.
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Received: 20 November 2014
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2015, Vol. 32 
