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| Expression of Macrophage Migration Inhibition Factor and Related Factors in Cervical Squamous Carcino-ma and Its Significance |
| YIN Qiao-yan%BU Lan-nan |
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Abstract [Objective] To explore the expression of macrophage migration inhibition factor(MIF) ,metalloprotease‐9 (MMP‐9) and vascular endothelial growth factor(VEGF) in squamous carcinoma of the cervix(SCC) .[Methods]A total of 51 SCC samples(SCC group) ,41 cervical intraepithelial neoplasia(CIN) samples(CIN group) and 32 normal cervix (NCE) sample(NCE group) were chosen .The expressions of MIF ,MMP‐9 and VEGF were detected by immunohisto‐chemical SP method ,and compared and analyzed .[Results] The positive rates of MIF ,MMP‐9 and VEGF and MVD value in NCE ,CIN and SCC groups were increased by turns ,and there was significant difference( P<0 .05) ,and those in SCC group were markedly higher than those in CIN and NCE groups .The positive expression rates of MIF ,MMP‐9 and VEGF in SCC group were correlated with histological differentiation ,lymph node metastasis and clinical stage( P<0 .05) .The positive expression rates of MIF ,MMP‐9 and VEGF and MVD value were markedly correlated with clinical stage ,differentiation and lymph node metastasis of SCC( P<0 .05) .The expression of MIF in SCC was markedly corre‐lated with the expression of MMP‐9( P<0 .05) ,but the expression of VEGF was not correlated with the expressions of MIF and MMP‐9( P>0 .05) .[Conclusion]MIF ,MMP‐9 and VEGF may play an important role in the occurrence ,de‐velopment ,infiltration and metastasis of SCC .The poorer the histological differentiation of SCC is ,the higher the expres‐sions of MIP ,MMP‐9 and VEGF and MVD value are .It indicates that the combination detection can evaluate the severity of SCC .
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2015, Vol. 32 
