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Abstract [Objective]To explore the clinical efficacy of prostaglandin e1 plus acarbose and its effects on oxidative stress in patients with type 2 diabetic nephropathy (DN) .[Methods]A total of 85 cases of type 2 DN fulfilling the inclusion criteria were divided into two groups according to therapeutic protocol .Besides conven‐tional treatments ,the control group treated acarbose 100 mg ,thrice daily while the observation group took prostaglandin e1 10 μg ,once daily and acarbose 100 mg thrice daily .Then their curative efficacy ,renal func‐tion ,oxidative stress and adverse reactions were observed and compared .[Results]The observation group had a therapeutic efficiency ratio (TER) of 88 .9% and it was significantly higher than that of 77 .5% in control group (Z=2 .15 ,P <0 .05) .In comparison with control group after treatment ,the renal function indices of blood urea nitrogen ,serum creatinine and urine total protein were statistically lower in observation group ( P<0 .05) .As to oxidative stress ,compared to control group ,malondialdehyde were statistically lower while superoxide dismutase was statistically higher in observation group ( P <0 .05) .During treatment ,there was on onset of severe adverse reactions .[Conclusion]Combined treatment of prostaglandin e1 and acarbose is effi‐cacious for type 2 DN .It can significantly increase therapeutic efficiency ratio ,improve renal function and alle‐viate oxidative stress with minor adverse reactions .
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2015, Vol. 32 
